Developmental Biology
Developmental Biology
11th Edition
ISBN: 9781605354705
Author: Scott F. Gilbert, Michael J. F. Barresi
Publisher: Sinauer Associates is an imprint of Oxford University Press
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Chapter 22, Problem 2DQ
Summary Introduction

To review:

Whether ErK signaling positively regulate Notum gene expression. The role of noncanonical Wnt signaling pathways in planarian regeneration.

Introduction:

The head-versus-tail regeneration decision in planarians, known as regeneration polarity, is a model for studying appropriate regeneration program specification. Wnt signaling controls regeneration polarity, with pathway components β-catenin-1 and wnt1 required to prevent head regeneration and promote tail regeneration at posterior-facing wounds. Wnt1 expression is upregulated near both anterior- and posterior-facing wounds. Notum (RNAi) animals regenerate an anterior-facing tail instead of a head, and double-RNAi experiments indicate notum inhibits Wnt signaling to promote head regeneration. notum expression is itself controlled by Wnt signaling, suggesting regulation of feedback inhibition controls the binary head-tail regeneration outcome.

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Developmental Biology

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