(a) Interpretation: The synthesis of N, N-Disubstituted amide from benzene as the only starting material is to be shown. Concept introduction: Electrophilic addition reactions disturb benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone , in which C atom from benzene form a bond to the carbon atom of the acyl group. For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Question

Want to see the full answer?

Answer 1

Question

Chapter 22, Problem 22.21P

Interpretation Introduction

(a)

Interpretation:

The synthesis of N, N-Disubstituted amide from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions disturb benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Interpretation Introduction

(b)

Interpretation:

The synthesis of imine from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions finish benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Predict the major products of this reaction: excess H+ NaOH ? A Note that the first reactant is used in excess, that is, there is much more of the first reactant than the second. If there won't be any products, just check the box under the drawing area instead. Explanation Check Click and drag to start drawing a structure. © 2025 McGraw Hill LLC. All Rights Reserved. Terms of Use Priv

1. For each of the reaction "railroads" below, you are either asked to give the structure(s) of the starting material(s) or product(s), or provide reagents/conditions to accomplish the transformation, as indicated by the boxes. a. NaOMe H+ .CO,H HO₂C MeOH (excess) MeOH H3C Br يع CH3 1. LiAlH4 2. H3O+ 3. PBг3 H3C 1. Et-Li 2. H3O+ -CO₂Me -CO₂Me OH CH3 CH3 ল CH3

Predict the intermediate 1 and final product 2 of this organic reaction: NaOMe ག1, ད།་, - + H You can draw 1 and 2 in any arrangement you like. 2 work up Note: if either 1 or 2 consists of a pair of enantiomers, just draw one structure using line bonds instead of 3D (dash and wedge) bonds at the chiral center. Explanation Check Click and drag to start drawing a structure. Х © 2025 McGraw Hill LLC. All Rights Reserved. Terms of Use | P

Answer 2

Question

Chapter 22, Problem 22.21P

Interpretation Introduction

(a)

Interpretation:

The synthesis of N, N-Disubstituted amide from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions disturb benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Interpretation Introduction

(b)

Interpretation:

The synthesis of imine from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions finish benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 22, Problem 22.21P

Interpretation Introduction

(a)

Interpretation:

The synthesis of N, N-Disubstituted amide from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions disturb benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Interpretation Introduction

(b)

Interpretation:

The synthesis of imine from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions finish benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 22, Problem 22.21P

Interpretation Introduction

(a)

Interpretation:

The synthesis of N, N-Disubstituted amide from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions disturb benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Interpretation Introduction

(b)

Interpretation:

The synthesis of imine from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions finish benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 22, Problem 22.21P

Interpretation Introduction

(a)

Interpretation:

The synthesis of N, N-Disubstituted amide from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions disturb benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Interpretation Introduction

(b)

Interpretation:

The synthesis of imine from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions finish benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Answer 6

Chapter 22, Problem 22.21P

Interpretation Introduction

(a)

Interpretation:

The synthesis of N, N-Disubstituted amide from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions disturb benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Answer 7

Chapter 22, Problem 22.21P

Interpretation Introduction

(a)

Interpretation:

The synthesis of N, N-Disubstituted amide from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions disturb benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The synthesis of imine from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions finish benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The synthesis of imine from benzene as the only starting material is to be shown.

Concept introduction:

Electrophilic addition reactions finish benzene’s aromaticity forever. Electrophilic aromatic substitution reactions grant the permission to incorporate lots of substituents onto an aromatic ring, however, most of the substituent cannot be put in place directly to the aromatic ring. To incorporate these kinds of the substituents on the benzene ring by first using electrophilic aromatic substituents reaction to incorporate different substituents that are subsequently transformed into the desired product. A Friedel–Crafts acylation of benzene is carried out with acyl chloride and lewis acid., which yield an aromatic ketone, in which C atom from benzene form a bond to the carbon atom of the acyl group.

For incorporate an amino group into a ring needs a substituent attached on the aromatic ring is attached by a carbon atom. This requires the benzylic carbon to be bonded at least one hydrogen atom. Further, this nitro group can be transformed into an amino group. This reduction can be carried out either by catalytic hydrogenation under acidic conditions followed by treatment with NaOH to neutralize the acid.

Answer 10

Expert Solution & Answer

Answer 11

Expert Solution & Answer

Answer 12

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 13

Ch. 22 - Prob. 22.1P Ch. 22 - Prob. 22.2P Ch. 22 - Prob. 22.3P Ch. 22 - Prob. 22.4P Ch. 22 - Prob. 22.5P Ch. 22 - Prob. 22.6P Ch. 22 - Prob. 22.7P Ch. 22 - Prob. 22.8P Ch. 22 - Prob. 22.9P Ch. 22 - Prob. 22.10P

Want to see the full answer?

Chapter 22 Solutions