
Interpretation:
Mechanisms for the three steps involved in the trapping of β- lactamase by tazobactum such as a) the reaction of the hydroxyl group on the β- lactamase to open the β- lactum ring of tazobactum b) The opening of the sulfur-containing ring in tazobactum to give an acyclic imine intermediate c) Cyclization of the imine intermediate to yield trapped β- lactamase product are to be proposed.
Concept introduction:
Three steps are involved in the conversion required. i ) Nucleophilic attack of β- lactamase on tazobactum to open the β- lactum ring ii) Formation of an imine intermediate by opening of the sulfur-containing ring in tazobactum iii) Cyclization to yield the trapped β- lactamase. All the three reactions involve the attack of nucleophiles.
To propose:
Mechanisms for the three steps involved in the trapping of β- lactamase by tazobactum such as a) the reaction of the hydroxyl group on the β- lactamase to open the β- lactum ring of tazobactum b) The opening of the sulfur-containing ring in tazobactum to give an acyclic imine intermediate c) Cyclization of the imine intermediate to yield trapped β- lactamase product.

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Chapter 21 Solutions
EBK ORGANIC CHEMISTRY
- Identify whether the carbocation or alkyl halide is methyl, primary, secondary, or tertiary.arrow_forwardDraw the products formed when the following alkene is treated with 03 followed by Zn, H₂O. Click the "draw structure" button to launch the drawing utility. draw structure ...arrow_forwardCalculate the pH of 0.600 M solution of CH5N (Kb=4.37 x10-4) Hint: use assumption and check it!arrow_forward
- Draw all stereoisomers formed when the following alkene is treated with mCPBA. Be sure to answer all parts. Part 1: How many stereoisomers of the product are possible? 1 Part 2 out of 2 Draw the product of the reaction, including stereochemistry. edit structure ...arrow_forwardA 3.30x10-2 M solution of monoprotic acid HA has a pH of 3.62. a) what is the percent ionization of this acid? b) what is the Ka of this acid?arrow_forwardIdentify as E1 or E2 and write the mechanism.arrow_forward
- Identify if their reaction is most likely SN1 or SN2 mechanism.arrow_forwardDraw the products formed when the following alkene is treated with 03 followed by Zn, H₂O. Be sure to answer all parts. draw structure ... smaller molar mass product draw structure ... larger molar mass productarrow_forwardComplete the two step reaction show the mechanism for all steps.arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage LearningIntroduction to General, Organic and BiochemistryChemistryISBN:9781285869759Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar TorresPublisher:Cengage Learning


