Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 21.L1, Problem 4WC
a. Which diseases in this chapter are zoonoses?
b. Name them and the major vector involved.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 21 Solutions
Foundations in Microbiology
Ch. 21.1 - Differentiate among the different stages of...Ch. 21.1 - Prob. 2ELOCh. 21.1 - List the nonsyphilitic treponematoses.Ch. 21.1 - Prob. 4ELOCh. 21.1 - Identify the vectors and behaviors associated with...Ch. 21.1 - Construct a table comparing the symptoms of...Ch. 21.1 - Prob. 2CYPCh. 21.1 - Besides syphilis, what other diseases are caused...Ch. 21.1 - List several behaviors that would put one at risk...Ch. 21.2 - Relate the physical characteristics seen in the...
Ch. 21.2 - Understand the pathogenesis of cholera.Ch. 21.2 - Name the usual source of infection for each genus...Ch. 21.2 - Prob. 9ELOCh. 21.2 - How could one differentiate the genera Vibrio,...Ch. 21.2 - Prob. 6CYPCh. 21.2 - Which two species of curviform bacteria are...Ch. 21.2 - Briefly describe the nature of food infection in...Ch. 21.2 - Prob. 9CYPCh. 21.3 - Prob. 10ELOCh. 21.3 - Understand the epidemiology and pathology of Rocky...Ch. 21.3 - Prob. 12ELOCh. 21.3 - Prob. 13ELOCh. 21.3 - Prob. 14ELOCh. 21.3 - Recall the names and characteristics of diseases...Ch. 21.3 - What do rickettsias and chlamydias derive from the...Ch. 21.3 - Provide an example of a species, vector, and...Ch. 21.3 - Prob. 12CYPCh. 21.3 - Prob. 13CYPCh. 21.3 - Prob. 14CYPCh. 21.3 - Prob. 15CYPCh. 21.3 - Prob. 16CYPCh. 21.3 - Prob. 17CYPCh. 21.4 - Describe the characteristics and diseases of...Ch. 21.4 - Describe how L forms may arise.Ch. 21.4 - Prob. 18CYPCh. 21.4 - Prob. 19CYPCh. 21.4 - Which body systems are affected by mycoplasma...Ch. 21.4 - Explain why penicillin therapy may result in the...Ch. 21.5 - Discuss the formation of plaque on tooth surfaces.Ch. 21.5 - Relate the formation of plaque to periodontitis.Ch. 21.5 - Prob. 22CYPCh. 21.5 - Prob. 23CYPCh. 21.5 - Prob. 24CYPCh. 21.5 - Prob. 25CYPCh. 21.L1 - Prob. 1MCQCh. 21.L1 - Prob. 2MCQCh. 21.L1 - Prob. 3MCQCh. 21.L1 - Prob. 4MCQCh. 21.L1 - Prob. 5MCQCh. 21.L1 - Prob. 6MCQCh. 21.L1 - Relapsing fever is spread by a. lice b. ticks c....Ch. 21.L1 - Prob. 8MCQCh. 21.L1 - Prob. 9MCQCh. 21.L1 - Prob. 10MCQCh. 21.L1 - Prob. 11MCQCh. 21.L1 - Prob. 12MCQCh. 21.L1 - Prob. 13MCQCh. 21.L1 - Prob. 14MCQCh. 21.L1 - Mycoplasmas attack the ____ of host cells. a....Ch. 21.L1 - Prob. 16MCQCh. 21.L1 - Prob. 17MCQCh. 21.L1 - Prob. 18MCQCh. 21.L1 - Prob. 19MCQCh. 21.L1 - Prob. 20MCQCh. 21.L1 - Prob. 1CSRCh. 21.L1 - What other risk factors could have alerted...Ch. 21.L1 - What characteristics of Coxiella are important...Ch. 21.L1 - Prob. 1WCCh. 21.L1 - Prob. 2WCCh. 21.L1 - a. In what ways are dental diseases mixed...Ch. 21.L1 - a. Which diseases in this chapter are zoonoses? b....Ch. 21.L2 - a. Why does syphilis have such profound effects on...Ch. 21.L2 - a. In view of the fact that cholera causes the...Ch. 21.L2 - Prob. 3CTCh. 21.L2 - Prob. 4CTCh. 21.L2 - Prob. 5CTCh. 21.L2 - Prob. 6CTCh. 21.L2 - Prob. 7CTCh. 21.L2 - Which two infectious agents covered in this...Ch. 21.L2 - a. In what way is the oral cavity an ecological...Ch. 21.L2 - Prob. 10CTCh. 21.L2 - Prob. 11CTCh. 21.L2 - Prob. 12CTCh. 21.L2 - Prob. 1VC
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