Inquiry into Life
16th Edition
ISBN: 9781260482638
Author: Mader, Sylvia
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 21.6, Problem 1QTC
There are undeniable benefits to the use of pesticides, one of the major ones being more attractive, insect-free food. How would you personally weigh these benefits compared to the risks to ingesting endocrine disrupting contaminants?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 21 Solutions
Inquiry into Life
Ch. 21.1 - Prob. 1LOCh. 21.1 - Prob. 2LOCh. 21.1 - Analyze the role of gonadotropin-releasing...Ch. 21.1 - Prob. 1CYPCh. 21.1 - Prob. 2CYPCh. 21.1 - Prob. 3CYPCh. 21.2 - Prob. 1LOCh. 21.2 - 2. Discuss the major components of the female...Ch. 21.2 - Prob. 3LOCh. 21.2 - Prob. 1CYP
Ch. 21.2 - Prob. 2CYPCh. 21.2 - Prob. 3CYPCh. 21.3 - List the stages of the ovarian cycle and explain...Ch. 21.3 - Prob. 2LOCh. 21.3 - Prob. 3LOCh. 21.3 - Prob. 4LOCh. 21.3 - Summarize the events that occur during the two...Ch. 21.3 - Prob. 2CYPCh. 21.3 - Describe the changes that occur in the ovarian and...Ch. 21.4 - Distinguish digital birth control methods that are...Ch. 21.4 - Prob. 2LOCh. 21.4 - Prob. 3LOCh. 21.4 - Prob. 1CYPCh. 21.4 - Prob. 2CYPCh. 21.4 - Prob. 3CYPCh. 21.4 - Prob. 4CYPCh. 21.5 - List the specific cause and common symptoms of...Ch. 21.5 - Prob. 2LOCh. 21.5 - Prob. 3LOCh. 21.5 - Prob. 4LOCh. 21.5 - Prob. 1QTCCh. 21.5 - Prob. 2QTCCh. 21.5 - Prob. 3QTCCh. 21.5 - Prob. 1AQTCCh. 21.5 - What cultural factors may be inhibiting the...Ch. 21.5 - Prob. 1CYPCh. 21.5 - Prob. 2CYPCh. 21.5 - Prob. 3CYPCh. 21.5 - Explain why viral diseases, in general, are more...Ch. 21.6 - Describe some common disorders of the male...Ch. 21.6 - 2. Describe some common disorders of the female...Ch. 21.6 - 3. Discuss four assisted reproductive technology...Ch. 21.6 - There are undeniable benefits to the use of...Ch. 21.6 - How might chronic-disrupting chemicals specially...Ch. 21.6 - 3. What would be some implications for agriculture...Ch. 21.6 - Explain how sildenafil(Viagra®) and singular...Ch. 21.6 - 2. Describe how endometriosis causes...Ch. 21.6 - 3. List some factors that explain why ovary and...Ch. 21.6 - 4. Compare the degree of medical intervention...Ch. 21 - Prob. S5.4BYBCh. 21 - Prob. S20.1BYBCh. 21 - Prob. S20.6BYBCh. 21 - Prob. 1ACh. 21 - Prob. 2ACh. 21 - Spermatogenesis occur in the structure of the male...Ch. 21 - Prob. 4ACh. 21 - Prob. 5ACh. 21 - Prob. 6ACh. 21 - The release of the oocyte from the follicle is...Ch. 21 - Prob. 8ACh. 21 - Prob. 9ACh. 21 - Prob. 10ACh. 21 - Prob. 11ACh. 21 - Prob. 12ACh. 21 - Prob. 13ACh. 21 - Prob. 14ACh. 21 - Prob. 15ACh. 21 - Prob. 16ACh. 21 - Prob. 1TCCh. 21 - Prob. 2TCCh. 21 - The condition called benign prostatic hyperplasia...Ch. 21 - Prob. 4TC
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