Chapter 21.4, Problem 10P

Interpretation Introduction

(a)

Interpretation: The enolates that are formed by the reaction of the given ketone with LDA present in the THF solution and with ${\text{NaOCH}}_{\text{3}}$ present in ${\text{CH}}_{\text{3}}\text{OH}$ solution are to be identified.

Concept introduction: The replacement or substitution of one functional group with another different functional group in any chemical reaction is termed as substitution reaction. The nucleophilic reaction that consists of bimolecular as well as bond-making and bond-breaking steps is termed as ${\text{S}}_{\text{N}}\text{2}$ reactions. This is a one-step reaction in which both nucleophile and substrate participate in the rate determining step.

The bulky base like LDA always abstracts the proton from the side of less substituted $\text{C}-\text{atom}$. The strong base, ${\text{NaOCH}}_{\text{3}}$ which is present in protic solvent like ${\text{CH}}_{\text{3}}\text{OH}$ always favors the elimination of the proton from the side of more substituted $\text{C}-\text{atom}$.

Interpretation Introduction

(b)

Interpretation: The enolates that are formed by the reaction of the given ketone with LDA present in the THF solution and with ${\text{NaOCH}}_{\text{3}}$ present in ${\text{CH}}_{\text{3}}\text{OH}$ solution are to be identified.

Concept introduction: The replacement or substitution of one functional group with another different functional group in any chemical reaction is termed as substitution reaction. The nucleophilic reaction that consists of bimolecular as well as bond-making and bond-breaking steps is termed as ${\text{S}}_{\text{N}}\text{2}$ reactions. This is a one-step reaction in which both nucleophile and substrate participate in the rate determining step.

The bulky base like LDA always abstracts the proton from the side of less substituted $\text{C}-\text{atom}$. The strong base, ${\text{NaOCH}}_{\text{3}}$ which is present in protic solvent like ${\text{CH}}_{\text{3}}\text{OH}$ always favors the elimination of the proton from the side of more substituted $\text{C}-\text{atom}$.

Interpretation Introduction

(c)

Interpretation: The enolates that are formed by the reaction of the given ketone with LDA present in the THF solution and with ${\text{NaOCH}}_{\text{3}}$ present in ${\text{CH}}_{\text{3}}\text{OH}$ solution are to be identified.

Concept introduction: The replacement or substitution of one functional group with another different functional group in any chemical reaction is termed as substitution reaction. The nucleophilic reaction that consists of bimolecular as well as bond-making and bond-breaking steps is termed as ${\text{S}}_{\text{N}}\text{2}$ reactions. This is a one-step reaction in which both nucleophile and substrate participate in the rate determining step.

The bulky base like LDA always abstracts the proton from the side of less substituted $\text{C}-\text{atom}$. The strong base, ${\text{NaOCH}}_{\text{3}}$ which is present in protic solvent like ${\text{CH}}_{\text{3}}\text{OH}$ always favors the elimination of the proton from the side of more substituted $\text{C}-\text{atom}$.