Concept explainers
(a)
To write: The overall equation for the transfer of one acetyl group from the mitochondrion to the cytosol.
Introduction:
Mitochondria synthesizes acetyl-CoA by reactions such as “oxidative carboxylation of pyruvate”, amino acid catabolism, and β-oxidation of fatty acids. Transportation of acetyl-CoA through the “inner mitochondrial membrane” to cytosol occurs by two mechanisms: carnitine dependent transport and citrate shuttle.
(b)
To determine: The cost of the process of the transfer of one acetyl group from mitochondrion to the cytosol.
Introduction:
Mitochondria synthesizes acetyl-CoA by reactions such as “oxidative carboxylation of pyruvate”, amino acid catabolism, and β-oxidation of fatty acids. Transportation of acetyl-CoA through the “inner mitochondrial membrane” to cytosol occurs by two mechanisms: carnitine dependent transport and citrate shuttle.
(c)
To determine: If acetyl group shuttle in the transfer of fatty acyl-CoA from the cytosol to the mitochondrion in preparation for β-oxidation result in separation of the mitochondrial and cytosolic pool of Co-A.
Introduction:
Mitochondria synthesizes acetyl-CoA by reactions such as “oxidative carboxylation of pyruvate”, amino acid catabolism, and β-oxidation of fatty acids. Transportation of acetyl-CoA by through the “inner mitochondrial membrane” to cytosol occurs by two mechanisms: carnitine dependent transport and citrate shuttle.
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