The synthesis of anastrozole from the given compounds is to be devised. Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively. The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 21, Problem 65P

Interpretation Introduction

Interpretation: The synthesis of anastrozole from the given compounds is to be devised.

Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.

The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

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1) Draw the structures of D-lysine and L-lysine and assign R/S configuration (showing your workings). 2) Draw the predominant ionisation forms of the free amino acid lysine, at pH 1.0, 8.0, and 11.0. pKa values: 2.2 (-COOH), 9.0 (α-NH3+), 10.5 (side-chain). 3) Calculate (showing your workings) the % of the different ionized species that are present in a 1.00 M solution of L-proline at pH = 10.0. pKa values: 1.95 (- COOH), 10.64 (α-NH3*). 4) a) Draw the tripeptide Tyr-Pro-Lys once with a trans peptide bond between Tyr and Pro and once with a cis peptide bond between Tyr and Pro. b) The electrospray ionization mass spectrum (ESI-MS) of the tripeptide you designed in part (a) shows peaks indicative of mono-protonation and di- protonation of the tripeptide. At what values of m/z would these peaks be expected (no fragmentation)? Briefly explain your answer (showing your workings). 5) How could the sequence of Ala-Met-Thr be distinguished from that of Thr-Ala- Met by tandem ESI-MS-MS?…

LABORATORY REPORT FORM Part I. Determination of the Formula of a Known Hydrate 1. Mass of empty evaporating dish 3. Mass of hydrate Using subtraction or mass by difference, find the mass of the hydrate 76.96 -75.40 75.40g 76.968 1.568 01.56 76.90 g 2. Mass of evaporating dish + hydrate 4. Mass of evaporating dish + hydrate (after heating) First 76.98 g Third 76.66g Second Fourth (if necessary) 76.60g 5. Mass of anhydrate 6. Mass of water lost by the hydrate 7. Percent of water of hydration (Show Calculations) 8. Moles of water (Show Calculations) mol mass of water = MM of water (g/m) 9. Moles of anhydrate (Show Calculations) 10. Ratio of moles of water to moles of anhydrate 11 F(Show Calculations) 11. Formula of hydrate - Mass of water (g) x 100 % water hydration g g % Mass of hydrate (9) x IC % = (Mass of hydrate- mass of an) mass of hydrate (g) % = (1.569- × 100= mol 1.569 mol Mol Mass of anhydrate/MM of anhydrate 12. What was the color of the hydrate? blue What was the color of the…

compared t-critical with t-calculated and 95% confidence interval to answer this question

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 21, Problem 65P

Interpretation Introduction

Interpretation: The synthesis of anastrozole from the given compounds is to be devised.

Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.

The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

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Answer 3

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 21, Problem 65P

Interpretation Introduction

Interpretation: The synthesis of anastrozole from the given compounds is to be devised.

Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.

The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

Expert Solution & Answer

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Check out a sample textbook solution

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Answer 4

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 21, Problem 65P

Interpretation Introduction