Genetics: Analysis and Principles
Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 21, Problem 4EQ
Summary Introduction

To analyze:

To determine which selectable markers are used in the chimeric mouse production to identify the chimeric mouse.

Introduction:

Mice are used in gene targeting technology for humanized, knock in and knock out models. The homologous recombination refers to the genetic recombination in which the DNA segments are exchanged between two similar or identical DNA molecules. When the mouse is homozygous for a particular gene (inactivated) in the human, such a gene is inactivated to determine its normal function; this process is called gene knock out.

Opposite togene knock out is gene knock in, in this, the gene is added into the particular site of the mouse to study its function.

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Genetics: Analysis and Principles

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