HUMAN ANATOMY
6th Edition
ISBN: 9781260210262
Author: SALADIN
Publisher: RENT MCG
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Chapter 2.1, Problem 4BYGO
Answer the following questions to test your understanding of the preceding section:
4. Define cytoplasm, cytosal, and organelle.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 2 Solutions
HUMAN ANATOMY
Ch. 2.1 - Prob. 1AWYKCh. 2.1 - Prob. 1BYGOCh. 2.1 - Prob. 2BYGOCh. 2.1 - Prob. 3BYGOCh. 2.1 - Answer the following questions to test your...Ch. 2.2 - Prob. 1AWYKCh. 2.2 - Prob. 2AWYKCh. 2.2 - Prob. 5BYGOCh. 2.2 - Compare the structure and function of...Ch. 2.2 - What membrane transport processes get all the...
Ch. 2.2 - Identify several reasons why the glycocalyx is...Ch. 2.2 - Prob. 9BYGOCh. 2.2 - Prob. 10BYGOCh. 2.3 - Not all genetic diseases are hereditary. Explain...Ch. 2.3 - Prob. 11BYGOCh. 2.3 - Prob. 12BYGOCh. 2.3 - Prob. 13BYGOCh. 2.3 - What three organelles are involved in protein...Ch. 2.3 - Prob. 15BYGOCh. 2.4 - State what occurs in each of the four phases of...Ch. 2.4 - Prob. 17BYGOCh. 2.4 - Prob. 18BYGOCh. 2.4 - Prob. 19BYGOCh. 2.4 - Discuss the advantages and disadvantages of adult...Ch. 2 - Prob. 2.1.1AYLOCh. 2 - How the light microscope transmission electron...Ch. 2 - Prob. 2.1.3AYLOCh. 2 - The distinction between the basal, apical, and...Ch. 2 - The size of a micrometer and some common and...Ch. 2 - Prob. 2.1.6AYLOCh. 2 - The meanings of plasma membrane, cytoplasm,...Ch. 2 - Prob. 2.1.8AYLOCh. 2 - Prob. 2.2.1AYLOCh. 2 - Prob. 2.2.2AYLOCh. 2 - Prob. 2.2.3AYLOCh. 2 - Prob. 2.2.4AYLOCh. 2 - The diverse physiological roles of membrane...Ch. 2 - Prob. 2.2.6AYLOCh. 2 - Prob. 2.2.7AYLOCh. 2 - Prob. 2.2.8AYLOCh. 2 - Prob. 2.2.9AYLOCh. 2 - Prob. 2.2.10AYLOCh. 2 - Prob. 2.2.11AYLOCh. 2 - The three components of the cytoskeleton, and how...Ch. 2 - Structure and function of a cell’s nucleus rough...Ch. 2 - Prob. 2.3.3AYLOCh. 2 - The four stages of the cell cycle and what events...Ch. 2 - The four stages of mitosis, what events occur in...Ch. 2 - Prob. 2.4.3AYLOCh. 2 - Prob. 2.4.4AYLOCh. 2 - The meaning of stem cells; their usefulness in...Ch. 2 - Prob. 1TYRCh. 2 - New nuclei form and a cell pinches in two during...Ch. 2 - Prob. 3TYRCh. 2 - Prob. 4TYRCh. 2 - Prob. 5TYRCh. 2 - Prob. 6TYRCh. 2 - Prob. 7TYRCh. 2 - Prob. 8TYRCh. 2 - Prob. 9TYRCh. 2 - Matter can leave a cell by any of the following...Ch. 2 - Prob. 11TYRCh. 2 - Prob. 12TYRCh. 2 - Prob. 13TYRCh. 2 - Prob. 14TYRCh. 2 - Prob. 15TYRCh. 2 - Prob. 16TYRCh. 2 - Prob. 17TYRCh. 2 - Prob. 18TYRCh. 2 - Prob. 19TYRCh. 2 - Prob. 20TYRCh. 2 - Prob. 1WWWTSCh. 2 - Prob. 2WWWTSCh. 2 - Prob. 3WWWTSCh. 2 - Prob. 4WWWTSCh. 2 - Briefly explain why each of the following...Ch. 2 - Prob. 6WWWTSCh. 2 - Prob. 7WWWTSCh. 2 - Prob. 8WWWTSCh. 2 - Prob. 9WWWTSCh. 2 - Briefly explain why each of the following...Ch. 2 - Prob. 1BYMVCh. 2 - Prob. 2BYMVCh. 2 - Prob. 3BYMVCh. 2 - Prob. 4BYMVCh. 2 - Prob. 5BYMVCh. 2 - Prob. 6BYMVCh. 2 - Prob. 7BYMVCh. 2 - Prob. 8BYMVCh. 2 - Prob. 9BYMVCh. 2 - State a meaning of each word element and give a...Ch. 2 - What would probably happen to the plasma membrane...Ch. 2 - Prob. 2TYCCh. 2 - Prob. 3TYCCh. 2 - Prob. 4TYCCh. 2 - Prob. 5TYC
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