Human Biology: Concepts and Current Issues
Human Biology: Concepts and Current Issues
7th Edition
ISBN: 9780321821652
Author: Michael D. Johnson
Publisher: Benjamin Cummings
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Chapter 21, Problem 12TY
Summary Introduction

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Telomeres are stretches of repeated nucleotide sequences at the chromosomal ends that prevent the degradation of chromosomal genes over time. As the enzymes involved in replication are not capable of replicating the ends, stretches from the ends are lost at every cycle of replication. So, when telomere is used up from the chromosome, cell division starts losing away the left-out chromosome portion leading to a huge loss in genetic information and finally seizing the process of cell division.

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The metabolic pathway below is used for the production of the purine nucleotides adenosine monophosphate (AMP) and guanosine monophosphate (GMP) in eukaryotic cells. Assume each arrow represents a reaction catalyzed by a different enzyme. Using the principles of feedback inhibition, propose a regulatory scheme for this pathway that ensures an adequate supply of both AMP and GMP, and prevents the buildup of Intermediates A through G when supplies of both AMP and GMP are adequate.
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