LIFE: THE SCIENCE OF BIOLOGY
11th Edition
ISBN: 9781319145125
Author: Sadava
Publisher: MAC HIGHER
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Chapter 20.5, Problem 1R
Summary Introduction
To review:
A hypothesis to explain that a deleterious allele, like sickle-cell anemia, could become fixed in a population.
Introduction:
Sickle-cell anemia is a genetic disease, which occurs in individuals, who are homozygous recessive for an allele that affects the hemoglobin gene. There is a strong negative selection against this allele, but it is quite common in central Africa, particularly in areas where malaria was highly prevalent historically.
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*Example 2: Tracing the path of an autosomal dominant trait
Trait: Neurofibromatosis
Forms of the trait:
The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein
neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous
tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a
cancerous form. i
The recessive form is a normal protein - in other words, no neurofibromatosis.moovi
A typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not
indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis
allele, and the letter "n" for the normal allele.
Nn
nn
nn
2
nn
Nn
A
3
N-
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Please finish the chart at the bottom. Some of the answers have been filled in.
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LIFE: THE SCIENCE OF BIOLOGY
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