Laboratory Manual for Human Anatomy
5th Edition
ISBN: 9781259683831
Author: Eric Wise, Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Chapter 20.4, Problem 14BYGO
Summary Introduction
To write:
About the cardiac cycle, systole and diastole along withthe effect of shortening the diastole on the heart rate and the duration of thecardiac cycle.
Introduction:
The terms cardiac cycle, systole, and diastole areassociated with the heart rate. Heart rate is defined as the number of times aheart beats in a minute. The rate of heartbeat varies depending on the need of anindividual's body.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 20 Solutions
Laboratory Manual for Human Anatomy
Ch. 20.1 - Answer the following questions to test you...Ch. 20.2 - Parts of the fibrous skeleton sometimes become...Ch. 20.2 - Prob. 3BYGOCh. 20.2 - Prob. 4BYGOCh. 20.2 - Answer the following questions to test you...Ch. 20.3 - Answer the following questions to test you...Ch. 20.3 - Prob. 7BYGOCh. 20.3 - Prob. 8BYGOCh. 20.3 - Answer the following questions to test you...Ch. 20.4 - Why should mitochondria be large and more abundant...
Ch. 20.4 - Answer the following questions to test you...Ch. 20.4 - Answer the following questions to test you...Ch. 20.4 - Prob. 12BYGOCh. 20.4 - Prob. 13BYGOCh. 20.4 - Prob. 14BYGOCh. 20.5 - Answer the following questions to test you...Ch. 20.5 - Answer the following questions to test you...Ch. 20.5 - Prob. 17BYGOCh. 20.5 - Answer the following questions to test you...Ch. 20 - Prob. 20.1.1AYLOCh. 20 - Prob. 20.1.2AYLOCh. 20 - Prob. 20.1.3AYLOCh. 20 - To test your knowledge, discuss the following...Ch. 20 - To test your knowledge, discuss the following...Ch. 20 - Prob. 20.1.6AYLOCh. 20 - Prob. 20.2.1AYLOCh. 20 - Prob. 20.2.2AYLOCh. 20 - Prob. 20.2.3AYLOCh. 20 - Reasons for the differences in muscularity between...Ch. 20 - Prob. 20.2.5AYLOCh. 20 - Prob. 20.2.6AYLOCh. 20 - The names, locations, and anatomy of the two...Ch. 20 - Prob. 20.2.8AYLOCh. 20 - Prob. 20.2.9AYLOCh. 20 - Prob. 20.2.10AYLOCh. 20 - Prob. 20.3.1AYLOCh. 20 - Prob. 20.3.2AYLOCh. 20 - Prob. 20.3.3AYLOCh. 20 - Prob. 20.3.4AYLOCh. 20 - Prob. 20.4.1AYLOCh. 20 - Prob. 20.4.2AYLOCh. 20 - Prob. 20.4.3AYLOCh. 20 - The Coronary Conduction System and Cardiac...Ch. 20 - Prob. 20.4.5AYLOCh. 20 - Prob. 20.5.1AYLOCh. 20 - Prob. 20.5.2AYLOCh. 20 - Prob. 20.5.3AYLOCh. 20 - Prob. 20.5.4AYLOCh. 20 - Prob. 20.5.5AYLOCh. 20 - Prob. 1TYRCh. 20 - To get from the right atrium to the right...Ch. 20 - There is/are_________ pulmonary vein(s) emptying...Ch. 20 - Prob. 4TYRCh. 20 - Prob. 5TYRCh. 20 - These are some of the points that the blood passes...Ch. 20 - The ascending aorta and pulmonary trunk develop...Ch. 20 - Prob. 8TYRCh. 20 - Blood in the anterior interventricular branch of...Ch. 20 - Which of these is not characteristic of the heart...Ch. 20 - Prob. 11TYRCh. 20 - The circulatory route from aorta to the venae...Ch. 20 - The circumflex branch of the left coronary artery...Ch. 20 - The finest passages through which electical...Ch. 20 - Electrical signal pass quickly from one...Ch. 20 - The abnormal bulging of the left AV valve into the...Ch. 20 - Prob. 17TYRCh. 20 - Prob. 18TYRCh. 20 - Prob. 19TYRCh. 20 - Prob. 20TYRCh. 20 - Prob. 1BYMVCh. 20 - Prob. 2BYMVCh. 20 - Prob. 3BYMVCh. 20 - Prob. 4BYMVCh. 20 - Prob. 5BYMVCh. 20 - Prob. 6BYMVCh. 20 - Prob. 7BYMVCh. 20 - Prob. 8BYMVCh. 20 - Prob. 9BYMVCh. 20 - Prob. 10BYMVCh. 20 - Prob. 1TOFCh. 20 - Prob. 2TOFCh. 20 - Prob. 3TOFCh. 20 - Prob. 4TOFCh. 20 - Briefly explain why each of the following...Ch. 20 - Prob. 6TOFCh. 20 - Briefly explain why each of the following...Ch. 20 - Prob. 8TOFCh. 20 - Prob. 9TOFCh. 20 - Prob. 10TOFCh. 20 - Prob. 1TYCCh. 20 - Becky, age 2, was born with a hole in her...Ch. 20 - Prob. 3TYCCh. 20 - Prob. 4TYCCh. 20 - Prob. 5TYC
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