EBK HUMAN ANATOMY & PHYSIOLOGY
16th Edition
ISBN: 8220100659836
Author: AMERMAN
Publisher: PEARSON
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Chapter 20.2, Problem 3QC
What are the body’s main surface barriers, and how do they function in its defense?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 20 Solutions
EBK HUMAN ANATOMY & PHYSIOLOGY
Ch. 20.1 - What are the main functions of the lymphatic...Ch. 20.1 - 2. How do lymphatic capillaries differ from blood...Ch. 20.1 - What is the pathway of lymph flow from the right...Ch. 20.1 - 4. What main cell types are located in lymphoid...Ch. 20.1 - List the main functions of MALT, lymph nodes, the...Ch. 20.2 - 1. How do innate immunity and adaptive immunity...Ch. 20.2 - 2. What are the three lines of defense?
Ch. 20.2 - What are the bodys main surface barriers, and how...Ch. 20.2 - Prob. 4QCCh. 20.2 - How are the immune system and lymphatic system...
Ch. 20.3 - Match the following cell types with their correct...Ch. 20.3 - Which of the cells in question 1 do not directly...Ch. 20.3 - What is the complement system, and what are its...Ch. 20.3 - In what two ways is the complement system...Ch. 20.3 - 5. What are the main cytokines of innate...Ch. 20.3 - What are the four cardinal signs of inflammation?Ch. 20.3 - 7. What are inflammatory mediators, and what do...Ch. 20.3 - Explain the role of phagocytes in the inflammatory...Ch. 20.3 - What causes the elevated temperature and common...Ch. 20.3 - Prob. 10QCCh. 20.4 - 1. What are MHC molecules?
Ch. 20.4 - 2. How do class I and class II MHC molecules...Ch. 20.4 - How are T cells activated?Ch. 20.4 - Prob. 4QCCh. 20.4 - What are the main functions of TC cells?Ch. 20.4 - Prob. 6QCCh. 20.4 - Prob. 7QCCh. 20.5 - 1. How is a B cell activated?
Ch. 20.5 - Prob. 2QCCh. 20.5 - What are the five classes of antibody, and how do...Ch. 20.5 - 4. List the five main functions of antibodies.
Ch. 20.5 - How do the primary and secondary immune responses...Ch. 20.5 - 6. What is the purpose of a vaccination, and what...Ch. 20.5 - 7. How do active immunity and passive immunity...Ch. 20.6 - How do innate immunity and adaptive immunity work...Ch. 20.6 - Walk through the basic steps of the immune...Ch. 20.6 - How does the immune system survey the body for...Ch. 20.6 - Walk through the steps of the immune response to...Ch. 20.6 - Prob. 5QCCh. 20.6 - 6. How do cancer cells escape the immune response...Ch. 20.7 - Define the four types of hypersensitivity...Ch. 20.7 - Explain how type IV hypersensitivity differs from...Ch. 20.7 - How do primary and secondary immunodeficiency...Ch. 20.7 - Prob. 4QCCh. 20.7 - What is an autoimmune disorder? What produces the...Ch. 20.7 - 6. What are the potential causes of autoimmune...Ch. 20 - 1. Which of the following is not a function of the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Fill in the blanks: The lymphoid organ that...Ch. 20 - Fill in the blanks: Nonspecific immunity is also...Ch. 20 -
5. Which of the following make up the body’s...Ch. 20 - Which of the following does not describe the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Which of the following functions is/are performed...Ch. 20 - Prob. 9CYRCh. 20 - 10. When naïve B cells are activated, they...Ch. 20 - 11. Match the following antibodies with the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Prob. 13CYRCh. 20 - On which type(s) of cells are class I MHC...Ch. 20 - Fill in the blanks: Class I MHC molecules display...Ch. 20 - 16. Which of the following is not a role of TH...Ch. 20 - 17. Mark the following statements as true or...Ch. 20 - 18. Type I hypersensitivity is due to release of...Ch. 20 - Prob. 19CYRCh. 20 - Prob. 20CYRCh. 20 - Prob. 1CYUCh. 20 - Complement proteins are crucial for stimulating...Ch. 20 - 3. Terrence has severe asthma and allergies, and...Ch. 20 - Your friend tests her snake-wrangling skills on an...Ch. 20 - 2. Carla presents to her physician with a...Ch. 20 - 3. Mr. White has been diagnosed with febrile...Ch. 20 - Mr. White developed neutropenia as a consequence...Ch. 20 - 5. The chemotherapeutic drugs Mr. White is taking...
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