Chapter 20.12, Problem 21P

Interpretation Introduction

Interpretation:

The reason for the statement that an amide cannot be prepared by acid-catalyzed condensation of amine and the carboxylic acid is to be stated.

Concept introduction:

The replacement or substitution of one functional group with another different functional group in any chemical reaction is termed as a substitution reaction.

In a nucleophilic substitution reaction, nucleophile takes the position of leaving the group by attacking the electron-deficient carbon atom.