MICROBIOLOGY-ACCESS >CUSTOM<
13th Edition
ISBN: 9780135668825
Author: Tortora
Publisher: PEARSON
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Textbook Question
Chapter 20, Problem 8R
The −OH is missing from carbon 39 in ddI. How does ddI inhibit DNA synthesis?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 20 Solutions
MICROBIOLOGY-ACCESS >CUSTOM<
Ch. 20 - DRAW IT Show where the following antibiotics work:...Ch. 20 - List and explain five criteria used to identify an...Ch. 20 - What similar problems are encountered with...Ch. 20 - Define drug resistance. How is it produced? What...Ch. 20 - List the advantages of using two chemotherapeutic...Ch. 20 - Why does a cell die from the following...Ch. 20 - How does each of the following inhibit...Ch. 20 - The OH is missing from carbon 39 in ddI. How does...Ch. 20 - Compare the method of action of the following...Ch. 20 - NAME IT This microorganism is not susceptible to...
Ch. 20 - Which of the following pairs is mismatched? a....Ch. 20 - Prob. 2MCQCh. 20 - Prob. 3MCQCh. 20 - An antimicrobial agent should meet all of the...Ch. 20 - The most selective antimicrobial activity would be...Ch. 20 - Prob. 6MCQCh. 20 - Which of the following will not affect eukaryotic...Ch. 20 - Cell membrane damage causes death because a. the...Ch. 20 - A drug that intercalates into DNA has the...Ch. 20 - Chloramphenicol binds to the 50S portion of a...Ch. 20 - Prob. 1ACh. 20 - Why is idoxuridine effective if host cells also...Ch. 20 - Some bacteria become resistant to tetracycline...Ch. 20 - The following data were obtained from a...Ch. 20 - Prob. 5ACh. 20 - The following results were obtained from a broth...Ch. 20 - Vancomycin-resistant Enterococcus faecalis was...Ch. 20 - Prob. 2CAECh. 20 - Prob. 3CAE
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