ANATOMY & PHYS VOL 2(CH 18-29) >CUSTOM<
9th Edition
ISBN: 9781307677720
Author: SALADIN
Publisher: MCG/CREATE
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Chapter 20, Problem 7BYMV
Summary Introduction
To build your medical vocabulary:
sapheno-
Meaning of the word element:
Standing
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 20 Solutions
ANATOMY & PHYS VOL 2(CH 18-29) >CUSTOM<
Ch. 20.1 - Prob. 1BYGOCh. 20.1 - Prob. 2BYGOCh. 20.1 - Prob. 3BYGOCh. 20.1 - Prob. 4BYGOCh. 20.1 - Prob. 5BYGOCh. 20.1 - Prob. 6BYGOCh. 20.1 - Definitions of arteries, veins, and capillaries...Ch. 20.1 - Prob. 2AYLOCh. 20.1 - Prob. 3AYLOCh. 20.1 - Prob. 4AYLO
Ch. 20.1 - Prob. 5AYLOCh. 20.1 - Prob. 6AYLOCh. 20.1 - Prob. 7AYLOCh. 20.1 - Prob. 8AYLOCh. 20.1 - Prob. 9AYLOCh. 20.1 - Prob. 10AYLOCh. 20.1 - Prob. 11AYLOCh. 20.1 - Prob. 12AYLOCh. 20.1 - Prob. 13AYLOCh. 20.1 - Prob. 14AYLOCh. 20.1 - Prob. 15AYLOCh. 20.2 - Prob. 7BYGOCh. 20.2 - Prob. 8BYGOCh. 20.2 - Prob. 9BYGOCh. 20.2 - Prob. 10BYGOCh. 20.2 - Prob. 11BYGOCh. 20.2 - Prob. 12BYGOCh. 20.2 - Prob. 1AYLOCh. 20.2 - Prob. 2AYLOCh. 20.2 - Prob. 3AYLOCh. 20.2 - Prob. 4AYLOCh. 20.2 - Why arterial expansion and recoil during the...Ch. 20.2 - Prob. 6AYLOCh. 20.2 - Prob. 7AYLOCh. 20.2 - Prob. 8AYLOCh. 20.2 - Prob. 9AYLOCh. 20.2 - Prob. 10AYLOCh. 20.2 - Prob. 11AYLOCh. 20.2 - Why blood velocity declines from aorta to...Ch. 20.2 - Prob. 13AYLOCh. 20.2 - Prob. 14AYLOCh. 20.2 - Prob. 15AYLOCh. 20.2 - Prob. 16AYLOCh. 20.2 - Prob. 17AYLOCh. 20.2 - Prob. 18AYLOCh. 20.2 - Prob. 19AYLOCh. 20.3 - Prob. 13BYGOCh. 20.3 - Prob. 14BYGOCh. 20.3 - Prob. 15BYGOCh. 20.3 - State the three fundamental causes of edema and...Ch. 20.3 - Prob. 1AYLOCh. 20.3 - Prob. 2AYLOCh. 20.3 - Prob. 3AYLOCh. 20.3 - Prob. 4AYLOCh. 20.3 - Prob. 5AYLOCh. 20.3 - Prob. 6AYLOCh. 20.3 - Relative amounts of fluid given off and reabsorbed...Ch. 20.3 - The role of solvent drag in capillary exchangeCh. 20.3 - Why the dynamics of capillary absorption can...Ch. 20.3 - Prob. 10AYLOCh. 20.3 - Prob. 11AYLOCh. 20.4 - Prob. 17BYGOCh. 20.4 - Prob. 18BYGOCh. 20.4 - Prob. 19BYGOCh. 20.4 - Prob. 1AYLOCh. 20.4 - Prob. 2AYLOCh. 20.4 - Prob. 3AYLOCh. 20.4 - Prob. 4AYLOCh. 20.4 - Prob. 5AYLOCh. 20.4 - Prob. 6AYLOCh. 20.4 - Prob. 7AYLOCh. 20.4 - Prob. 8AYLOCh. 20.5 - Prob. 20BYGOCh. 20.5 - Prob. 21BYGOCh. 20.5 - Prob. 22BYGOCh. 20.5 - Prob. 23BYGOCh. 20.5 - Prob. 1AYLOCh. 20.5 - Prob. 2AYLOCh. 20.5 - Prob. 3AYLOCh. 20.5 - Variability of skeletal muscle perfusion; what...Ch. 20.5 - Prob. 5AYLOCh. 20.6 - Prob. 24BYGOCh. 20.6 - Prob. 25BYGOCh. 20.6 - Prob. 1AYLOCh. 20.6 - Prob. 2AYLOCh. 20.6 - Prob. 3AYLOCh. 20.7 - Prob. 26BYGOCh. 20.7 - Prob. 27BYGOCh. 20.7 - Prob. 28BYGOCh. 20.7 - Prob. 29BYGOCh. 20.7 - For all named blood vessels in this outline, their...Ch. 20.7 - The ascending aorta, aortic arch, and descending...Ch. 20.7 - Branches that arise from the ascending aorta and...Ch. 20.7 - Four principal arteries of the neck: the common...Ch. 20.7 - The external and internal carotid arteries;...Ch. 20.7 - Prob. 6AYLOCh. 20.7 - Prob. 7AYLOCh. 20.7 - Dural venous sinuses; the superior sagittal,...Ch. 20.7 - Prob. 9AYLOCh. 20.7 - Prob. 10AYLOCh. 20.7 - Prob. 11AYLOCh. 20.7 - Prob. 12AYLOCh. 20.7 - Prob. 13AYLOCh. 20.7 - Branches of the abdominal aorta: inferior phrenic...Ch. 20.7 - Prob. 15AYLOCh. 20.7 - Prob. 16AYLOCh. 20.7 - Prob. 17AYLOCh. 20.7 - Prob. 18AYLOCh. 20.7 - Prob. 19AYLOCh. 20.7 - Prob. 20AYLOCh. 20.7 - Prob. 21AYLOCh. 20.7 - Prob. 22AYLOCh. 20.8 - Prob. 30BYGOCh. 20.8 - Prob. 31BYGOCh. 20.8 - Prob. 32BYGOCh. 20.8 - Prob. 33BYGOCh. 20.8 - Prob. 1AYLOCh. 20.8 - Prob. 2AYLOCh. 20.8 - Prob. 3AYLOCh. 20.8 - Prob. 4AYLOCh. 20.8 - Prob. 5AYLOCh. 20.8 - Prob. 6AYLOCh. 20.8 - Prob. 7AYLOCh. 20.8 - Prob. 8AYLOCh. 20.8 - Prob. 9AYLOCh. 20 - Blood often flows into a capillary bed from a. the...Ch. 20 - Prob. 2TYRCh. 20 - A blood vessel adapted to withstand a high pulse...Ch. 20 - Prob. 4TYRCh. 20 - Prob. 5TYRCh. 20 - Prob. 6TYRCh. 20 - Blood flows fester in a venule than in a capillary...Ch. 20 - In a case where interstitial hydrostatic pressure...Ch. 20 - Intestinal blood flows to the liver by way of a....Ch. 20 - Prob. 10TYRCh. 20 - The highest arterial blood pressure attained...Ch. 20 - Prob. 12TYRCh. 20 - Prob. 13TYRCh. 20 - Prob. 14TYRCh. 20 - Prob. 15TYRCh. 20 - Prob. 16TYRCh. 20 - Prob. 17TYRCh. 20 - Prob. 18TYRCh. 20 - Prob. 19TYRCh. 20 - Prob. 20TYRCh. 20 - Prob. 1BYMVCh. 20 - Prob. 2BYMVCh. 20 - Prob. 3BYMVCh. 20 - Prob. 4BYMVCh. 20 - Prob. 5BYMVCh. 20 - -orumCh. 20 - Prob. 7BYMVCh. 20 - Prob. 8BYMVCh. 20 - Prob. 9BYMVCh. 20 - Prob. 10BYMVCh. 20 - Prob. 1WWTSCh. 20 - Blood always passes through exactly one capillary...Ch. 20 - Prob. 3WWTSCh. 20 - Prob. 4WWTSCh. 20 - Prob. 5WWTSCh. 20 - The femoral triangle is bordered by the inguinal...Ch. 20 - Prob. 7WWTSCh. 20 - Prob. 8WWTSCh. 20 - Prob. 9WWTSCh. 20 - Prob. 10WWTSCh. 20 - Prob. 1TYCCh. 20 - Prob. 2TYCCh. 20 - Prob. 3TYCCh. 20 - Prob. 4TYCCh. 20 - Discuss why it is advantageous to have...
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