Chapter 20, Problem 51PP

Interpretation Introduction

Interpretation:

The efficient synthesis of target molecule should be drawn and identified for the given corresponding starting molecules by using its structures.

Concept introduction:

Addition Reaction: It is defined as chemical reaction in which two given molecules combines and forms product. The types of addition reactions are electrophilic addition, nucleophilic addition, free radical additions and cycloadditions. Generally, compounds with carbon-hetero atom bonds favors addition reaction.

Elimination Reaction: It is just reverse reaction of addition where substituent from the given molecule is removed via E1 (the reaction depends only on the substrate involved in the reaction) or E2 (the reaction depends on both of the substituents in the reaction) mechanism.

Acid Catalyzed Hydration Reaction: The reaction involves breaking of π-bonds between carbon-carbon multiple bonds and addition of alcohol to more substituted position of carbon in the molecule.

$S_{N}1$Reaction: The $S_{N}1$ reaction is twostep process, leaving group leaves the molecule is first step and forms the more stable carbocation. Further, nucleophile attacks the carbocation and forms the final product in the second step. The rate of the reaction depends on the stability of the carbocation.

$S_{N}2$Reaction: The $S_{N}2$ reaction is single step process, leaving group leaves the molecule and nucleophiles attack the molecule is single step process which is simultaneous process.

Grignard Reaction: This is a organometallic reaction in different alkyl, aryl-magnesium halides add to a carbonyl group in an aldehyde and ketone. This reaction is an important for the conversion of carbon-carbon single (-C-C-) bond. Moreover the addition of a reagent to an aster, lactone gives a tertiary alcohol in which wo alkyl groups are the same and the addition of a Grignard reagent to a nitrile produces an unsymmetrical ketone.

Halogenation: The addition of halogen atoms to a $\text{π-}$ conjunction system. The several unsaturated organic compounds like, alkenes, alkynes and cyclohexenes that has one double bond is halogenated, the resulting molecules is completely saturated or halogenated.

LAH Reduction: The saturated/unsaturated aldehyde and ketones in the presence of sodium metal in LAH and carbonyl compound produced saturated alcohols. The keto group involves in the reduction process of LAH, this end up reducing to give the alcohols.