Connect with LearnSmart Labs Access Card for Seeley's A&P
11th Edition
ISBN: 9781259807657
Author: Cinnamon VanPutte, Jennifer Regan, Andrew F. Russo Dr., Rod R. Seeley Dr.
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 20, Problem 3RAC
Summary Introduction
Introduction:
The heart pumps the blood, and the amount of blood that is pumped by it within one minute through the circulatory system is known as cardiac output. The normal range of cardiac output is 4700 mL/min.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 20 Solutions
Connect with LearnSmart Labs Access Card for Seeley's A&P
Ch. 20.1 - State the four functions of the heart.Ch. 20.2 - What is the approximate size and shape of the...Ch. 20.2 - Where is the heart located? How does this...Ch. 20.3 - Describe the parts of the pericardium and their...Ch. 20.3 - Describe the three layers of the heart wall, and...Ch. 20.3 - Name the chambers of the heart, and describe their...Ch. 20.3 - List the major blood vessels that enter and leave...Ch. 20.3 - Prob. 8AYPCh. 20.3 - Prob. 9AYPCh. 20.3 - Prob. 10AYP
Ch. 20.3 - Describe the openings of the right and left atria....Ch. 20.3 - Prob. 12AYPCh. 20.3 - Prob. 13AYPCh. 20.3 - Prob. 14AYPCh. 20.4 - Prob. 15AYPCh. 20.5 - Prob. 16AYPCh. 20.5 - Prob. 17AYPCh. 20.5 - Prob. 18AYPCh. 20.5 - Prob. 19AYPCh. 20.5 - Identify the parts of the conducting system of...Ch. 20.5 - Prob. 21AYPCh. 20.5 - Prob. 22AYPCh. 20.6 - Prob. 23AYPCh. 20.6 - Prob. 24AYPCh. 20.6 - Prob. 25AYPCh. 20.6 - Prob. 26AYPCh. 20.6 - What does an ECG measure? Nome the waves...Ch. 20.7 - Define systole and diastole.Ch. 20.7 - List the five periods of the cardiac cycle (see...Ch. 20.7 - Define isovolumetric. When does most ventricular...Ch. 20.7 - Prob. 31AYPCh. 20.7 - Prob. 32AYPCh. 20.7 - Prob. 33AYPCh. 20.8 - Prob. 34AYPCh. 20.8 - Explain the role of MAP in causing blood flow.Ch. 20.8 - Prob. 36AYPCh. 20.8 - Prob. 37AYPCh. 20.9 - Prob. 38AYPCh. 20.9 - Prob. 39AYPCh. 20.9 - Prob. 40AYPCh. 20.9 - Prob. 41AYPCh. 20.9 - Prob. 42AYPCh. 20.9 - Prob. 43AYPCh. 20.10 - Prob. 44AYPCh. 20.10 - Prob. 45AYPCh. 20.10 - What effect does an increase or a decrease...Ch. 20.10 - Prob. 47AYPCh. 20.11 - Prob. 48AYPCh. 20.11 - Prob. 49AYPCh. 20.11 - Prob. 50AYPCh. 20.11 - Prob. 51AYPCh. 20 - Which of these structures returns blood to the...Ch. 20 - Prob. 2RACCh. 20 - Prob. 3RACCh. 20 - Prob. 4RACCh. 20 - Prob. 5RACCh. 20 - Prob. 6RACCh. 20 - Action potentials pass from one cardiac muscle...Ch. 20 - During the transmission of action potentials...Ch. 20 - Given these structures of the conducting system of...Ch. 20 - Prob. 10RACCh. 20 - Prob. 11RACCh. 20 - The greatest amount of ventricular filling occurs...Ch. 20 - Prob. 13RACCh. 20 - Prob. 14RACCh. 20 - Prob. 15RACCh. 20 - Cardiac output is defined as blood pressure times...Ch. 20 - Pressure in the aorta is at its lowest a. at the...Ch. 20 - Prob. 18RACCh. 20 - Prob. 19RACCh. 20 - Prob. 20RACCh. 20 - Prob. 21RACCh. 20 - Increased parasympathetic stimulation of the heart...Ch. 20 - Prob. 23RACCh. 20 - Prob. 24RACCh. 20 - Prob. 25RACCh. 20 - Prob. 1CTCh. 20 - In most tissues, peak blood flow occurs during...Ch. 20 - Prob. 3CTCh. 20 - Prob. 4CTCh. 20 - A patient has tachycardia. Would you recommended a...Ch. 20 - Prob. 6CTCh. 20 - A doctor lets you listen to a patient's heart with...Ch. 20 - Explain why it is sufficient to replace the...Ch. 20 - Prob. 9CTCh. 20 - Prob. 10CTCh. 20 - Prob. 11CT
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