Using aniline as a starting material and 2-aminothiazole, the synthesis of sulfathiazole is to be shown and the conversion of sulfathiazole to succinylsulfathiazole is to be provided. Concept Introduction: ▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair. ▸ Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair. ▸ Free radical is an atom, molecule or ion that has an unpaired electron which makes it highly chemically reactive. ▸ Substitution reaction: A reaction in which one of the hydrogen atoms of a hydrocarbon or a functional group is substituted by any other functional group is called substitution reaction. ▸ Elimination reaction: A reaction in which two substituent groups are detached and a double bond is formed is called elimination reaction. ▸ Addition reaction: It is the reaction in which unsaturated bonds are converted to saturated molecules by the addition of molecules. ▸ Aniline and substituted aniline reacts with nitrous acid at low temperature to form benzene diazonium salts. ▸ The reduction of nitro group results in the formation of primary amine . ▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair. ▸ Carboxamide undergoes hydrolysis more rapidly than sulfonamide. ▸ The aniline undergoes acetylation to protect the amino group and form acetanilide. ▸ Acetanilide undergoes the electrophilic aromatic substitution on reaction with chlorosulfonic acid and yield p − acetamidobenzenesulfonyl . ▸ Addition of 2 − aminothiazole to p − acetamidobenzenesulfonyl and refluxing with dilute hydrochloric acid leads to the formation of sulfathiazole. ▸ The sulfathiazole reacts with the succinic anhydride which leads to the formation of final product that is succinylsulfathiazole.

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Answer 1

Question

Chapter 20, Problem 18PP

Interpretation Introduction

Interpretation:

Using aniline as a starting material and 2-aminothiazole, the synthesis of sulfathiazole is to be shown and the conversion of sulfathiazole to succinylsulfathiazole is to be provided.

Concept Introduction:

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair.

▸ Free radical is an atom, molecule or ion that has an unpaired electron which makes it highly chemically reactive.

▸ Substitution reaction: A reaction in which one of the hydrogen atoms of a hydrocarbon or a functional group is substituted by any other functional group is called substitution reaction.

▸ Elimination reaction: A reaction in which two substituent groups are detached and a double bond is formed is called elimination reaction.

▸ Addition reaction: It is the reaction in which unsaturated bonds are converted to saturated molecules by the addition of molecules.

▸ Aniline and substituted aniline reacts with nitrous acid at low temperature to form benzene diazonium salts.

▸ The reduction of nitro group results in the formation of primary amine.

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Carboxamide undergoes hydrolysis more rapidly than sulfonamide.

▸ The aniline undergoes acetylation to protect the amino group and form acetanilide.

▸ Acetanilide undergoes the electrophilic aromatic substitution on reaction with chlorosulfonic acid and yield p−acetamidobenzenesulfonyl.

▸ Addition of 2−aminothiazole to p−acetamidobenzenesulfonyl and refluxing with dilute hydrochloric acid leads to the formation of sulfathiazole.

▸ The sulfathiazole reacts with the succinic anhydride which leads to the formation of final product that is succinylsulfathiazole.

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4. Draw and label all possible isomers for [M(py)3(DMSO)2(CI)] (py = pyridine, DMSO dimethylsulfoxide).

Answer 2

Question

Chapter 20, Problem 18PP

Interpretation Introduction

Interpretation:

Using aniline as a starting material and 2-aminothiazole, the synthesis of sulfathiazole is to be shown and the conversion of sulfathiazole to succinylsulfathiazole is to be provided.

Concept Introduction:

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair.

▸ Free radical is an atom, molecule or ion that has an unpaired electron which makes it highly chemically reactive.

▸ Substitution reaction: A reaction in which one of the hydrogen atoms of a hydrocarbon or a functional group is substituted by any other functional group is called substitution reaction.

▸ Elimination reaction: A reaction in which two substituent groups are detached and a double bond is formed is called elimination reaction.

▸ Addition reaction: It is the reaction in which unsaturated bonds are converted to saturated molecules by the addition of molecules.

▸ Aniline and substituted aniline reacts with nitrous acid at low temperature to form benzene diazonium salts.

▸ The reduction of nitro group results in the formation of primary amine.

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Carboxamide undergoes hydrolysis more rapidly than sulfonamide.

▸ The aniline undergoes acetylation to protect the amino group and form acetanilide.

▸ Acetanilide undergoes the electrophilic aromatic substitution on reaction with chlorosulfonic acid and yield p−acetamidobenzenesulfonyl.

▸ Addition of 2−aminothiazole to p−acetamidobenzenesulfonyl and refluxing with dilute hydrochloric acid leads to the formation of sulfathiazole.

▸ The sulfathiazole reacts with the succinic anhydride which leads to the formation of final product that is succinylsulfathiazole.

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Answer 3

Question

Chapter 20, Problem 18PP

Interpretation Introduction

Interpretation:

Using aniline as a starting material and 2-aminothiazole, the synthesis of sulfathiazole is to be shown and the conversion of sulfathiazole to succinylsulfathiazole is to be provided.

Concept Introduction:

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair.

▸ Free radical is an atom, molecule or ion that has an unpaired electron which makes it highly chemically reactive.

▸ Substitution reaction: A reaction in which one of the hydrogen atoms of a hydrocarbon or a functional group is substituted by any other functional group is called substitution reaction.

▸ Elimination reaction: A reaction in which two substituent groups are detached and a double bond is formed is called elimination reaction.

▸ Addition reaction: It is the reaction in which unsaturated bonds are converted to saturated molecules by the addition of molecules.

▸ Aniline and substituted aniline reacts with nitrous acid at low temperature to form benzene diazonium salts.

▸ The reduction of nitro group results in the formation of primary amine.

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Carboxamide undergoes hydrolysis more rapidly than sulfonamide.

▸ The aniline undergoes acetylation to protect the amino group and form acetanilide.

▸ Acetanilide undergoes the electrophilic aromatic substitution on reaction with chlorosulfonic acid and yield p−acetamidobenzenesulfonyl.

▸ Addition of 2−aminothiazole to p−acetamidobenzenesulfonyl and refluxing with dilute hydrochloric acid leads to the formation of sulfathiazole.

▸ The sulfathiazole reacts with the succinic anhydride which leads to the formation of final product that is succinylsulfathiazole.

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Answer 4

Question

Chapter 20, Problem 18PP

Interpretation Introduction

Interpretation:

Using aniline as a starting material and 2-aminothiazole, the synthesis of sulfathiazole is to be shown and the conversion of sulfathiazole to succinylsulfathiazole is to be provided.

Concept Introduction:

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair.

▸ Free radical is an atom, molecule or ion that has an unpaired electron which makes it highly chemically reactive.

▸ Substitution reaction: A reaction in which one of the hydrogen atoms of a hydrocarbon or a functional group is substituted by any other functional group is called substitution reaction.

▸ Elimination reaction: A reaction in which two substituent groups are detached and a double bond is formed is called elimination reaction.

▸ Addition reaction: It is the reaction in which unsaturated bonds are converted to saturated molecules by the addition of molecules.

▸ Aniline and substituted aniline reacts with nitrous acid at low temperature to form benzene diazonium salts.

▸ The reduction of nitro group results in the formation of primary amine.

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Carboxamide undergoes hydrolysis more rapidly than sulfonamide.

▸ The aniline undergoes acetylation to protect the amino group and form acetanilide.

▸ Acetanilide undergoes the electrophilic aromatic substitution on reaction with chlorosulfonic acid and yield p−acetamidobenzenesulfonyl.

▸ Addition of 2−aminothiazole to p−acetamidobenzenesulfonyl and refluxing with dilute hydrochloric acid leads to the formation of sulfathiazole.

▸ The sulfathiazole reacts with the succinic anhydride which leads to the formation of final product that is succinylsulfathiazole.

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Answer 5

Chapter 20, Problem 18PP

Interpretation Introduction

Interpretation:

Using aniline as a starting material and 2-aminothiazole, the synthesis of sulfathiazole is to be shown and the conversion of sulfathiazole to succinylsulfathiazole is to be provided.

Concept Introduction:

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair.

▸ Free radical is an atom, molecule or ion that has an unpaired electron which makes it highly chemically reactive.

▸ Substitution reaction: A reaction in which one of the hydrogen atoms of a hydrocarbon or a functional group is substituted by any other functional group is called substitution reaction.

▸ Elimination reaction: A reaction in which two substituent groups are detached and a double bond is formed is called elimination reaction.

▸ Addition reaction: It is the reaction in which unsaturated bonds are converted to saturated molecules by the addition of molecules.

▸ Aniline and substituted aniline reacts with nitrous acid at low temperature to form benzene diazonium salts.

▸ The reduction of nitro group results in the formation of primary amine.

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Carboxamide undergoes hydrolysis more rapidly than sulfonamide.

▸ The aniline undergoes acetylation to protect the amino group and form acetanilide.

▸ Acetanilide undergoes the electrophilic aromatic substitution on reaction with chlorosulfonic acid and yield p−acetamidobenzenesulfonyl.

▸ Addition of 2−aminothiazole to p−acetamidobenzenesulfonyl and refluxing with dilute hydrochloric acid leads to the formation of sulfathiazole.

▸ The sulfathiazole reacts with the succinic anhydride which leads to the formation of final product that is succinylsulfathiazole.

Answer 6

Chapter 20, Problem 18PP

Interpretation Introduction

Interpretation:

Using aniline as a starting material and 2-aminothiazole, the synthesis of sulfathiazole is to be shown and the conversion of sulfathiazole to succinylsulfathiazole is to be provided.

Concept Introduction:

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair.

▸ Free radical is an atom, molecule or ion that has an unpaired electron which makes it highly chemically reactive.

▸ Substitution reaction: A reaction in which one of the hydrogen atoms of a hydrocarbon or a functional group is substituted by any other functional group is called substitution reaction.

▸ Elimination reaction: A reaction in which two substituent groups are detached and a double bond is formed is called elimination reaction.

▸ Addition reaction: It is the reaction in which unsaturated bonds are converted to saturated molecules by the addition of molecules.

▸ Aniline and substituted aniline reacts with nitrous acid at low temperature to form benzene diazonium salts.

▸ The reduction of nitro group results in the formation of primary amine.

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Carboxamide undergoes hydrolysis more rapidly than sulfonamide.

▸ The aniline undergoes acetylation to protect the amino group and form acetanilide.

▸ Acetanilide undergoes the electrophilic aromatic substitution on reaction with chlorosulfonic acid and yield p−acetamidobenzenesulfonyl.

▸ Addition of 2−aminothiazole to p−acetamidobenzenesulfonyl and refluxing with dilute hydrochloric acid leads to the formation of sulfathiazole.

▸ The sulfathiazole reacts with the succinic anhydride which leads to the formation of final product that is succinylsulfathiazole.

Answer 7

Chapter 20, Problem 18PP

Interpretation Introduction

Interpretation:

Using aniline as a starting material and 2-aminothiazole, the synthesis of sulfathiazole is to be shown and the conversion of sulfathiazole to succinylsulfathiazole is to be provided.

Concept Introduction:

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair.

▸ Free radical is an atom, molecule or ion that has an unpaired electron which makes it highly chemically reactive.

▸ Substitution reaction: A reaction in which one of the hydrogen atoms of a hydrocarbon or a functional group is substituted by any other functional group is called substitution reaction.

▸ Elimination reaction: A reaction in which two substituent groups are detached and a double bond is formed is called elimination reaction.

▸ Addition reaction: It is the reaction in which unsaturated bonds are converted to saturated molecules by the addition of molecules.

▸ Aniline and substituted aniline reacts with nitrous acid at low temperature to form benzene diazonium salts.

▸ The reduction of nitro group results in the formation of primary amine.

▸ Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

▸ Carboxamide undergoes hydrolysis more rapidly than sulfonamide.

▸ The aniline undergoes acetylation to protect the amino group and form acetanilide.

▸ Acetanilide undergoes the electrophilic aromatic substitution on reaction with chlorosulfonic acid and yield p−acetamidobenzenesulfonyl.

▸ Addition of 2−aminothiazole to p−acetamidobenzenesulfonyl and refluxing with dilute hydrochloric acid leads to the formation of sulfathiazole.

▸ The sulfathiazole reacts with the succinic anhydride which leads to the formation of final product that is succinylsulfathiazole.

Answer 8

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Ch. 20 - Prob. 1PP Ch. 20 - Prob. 2PP Ch. 20 - Practice Problem 20.3 Write a mechanism that...Ch. 20 - Prob. 4PP Ch. 20 - PRACTICE PROBLEM 20.5 Outline a preparation of...Ch. 20 - Prob. 6PP Ch. 20 - Prob. 7PP Ch. 20 - Prob. 8PP Ch. 20 - Prob. 9PP Ch. 20 - Prob. 10PP

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