Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Question
Chapter 20, Problem 18P
Interpretation Introduction
Interpretation:
Pertussis toxin ADP ribosylates the a subunit of Gi. To explain how this toxin affects blood pressure.
Concept Introduction:
Pertussis toxin catalyzes the ADP-ribosylation of the ai subunits of the heterotrimeric G protein. As a result the G protein is no longer able to interact with G protein-coupled receptors (GPCR) on the cell membrane. This inhibits downstream cell signaling.
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Biochemistry: Concepts and Connections (2nd Edition)
Ch. 20 - Prob. 1PCh. 20 - Prob. 2PCh. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - Prob. 5PCh. 20 - Prob. 6PCh. 20 - Prob. 7PCh. 20 - Prob. 8PCh. 20 - Prob. 9PCh. 20 - Prob. 10P
Ch. 20 - Suppose that a G protein undergoes a mutation that...Ch. 20 - Prob. 12PCh. 20 - Prob. 13PCh. 20 - Prob. 14PCh. 20 - Prob. 15PCh. 20 - Prob. 16PCh. 20 - Prob. 17PCh. 20 - Prob. 18PCh. 20 - Prob. 19PCh. 20 - Explain the effectiveness of Gleevec in treating...Ch. 20 - Prob. 21PCh. 20 - Prob. 22P
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