EBK FUNDAMENTALS OF BIOSTATISTICS
8th Edition
ISBN: 9781305465510
Author: Rosner
Publisher: YUZU
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Textbook Question
Chapter 2, Problem 34P
Activated-protein-C (APC) resistance is a serum marker that has been associated with thrombosis (the formation of blood clots often leading to heart attacks) among adults. A study assessed this risk factor among adolescents. To assess the reproducibility of the assay, a split-sample technique was used in which a blood sample was provided by 10 people; each sample was split into two aliquots (sub-samples), and each aliquot was assessed separately. Table 2.19 gives the results.
Table 2.19 APC resistance split-samples data
Compute the average CV over the 10 subjects as an overall measure of variability of the assay. In general, a CV of <10% is considered excellent, ≥10% and <20% is considered good, ≥20% and <30% is considered fair, and ≥30% is considered poor.
How would you characterize the reliability of the APC assay based on these criteria?
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Question 2
A nickel-titanium alloy is used to make components for jet turbine aircraft engines. Cracking is a potentially
serious problem in the final part because it can lead to nonrecoverable failure. A test is run at the parts producer
to determine the effect of four factors on cracks. The four factors are: pouring temperature (A), titanium content
(B), heat treatment method (C), amount of grain refiner used (D). Two replicates of a 24 design are run, and
the length of crack (in mm x10-2) induced in a sample coupon subjected to a standard test is measured. The
data are shown in Table 2.
1
(a) Estimate the factor effects. Which factor effects appear to be large?
(b) Conduct an analysis of variance. Do any of the factors affect cracking? Use a = 0.05.
(c) Write down a regression model that can be used to predict crack length as a function of the significant
main effects and interactions you have identified in part (b).
(d) Analyze the residuals from this experiment.
(e) Is there an…
A 24-1 design has been used to investigate the effect of four factors on the resistivity of a silicon wafer. The data
from this experiment are shown in Table 4.
Table 4: Resistivity Experiment for Exercise 5
Run
A
B
с
D
Resistivity
1
23
2
3
4
5
6
7
8
9
10
11
12
I+I+I+I+Oooo
0
0
||++TI++o000
33.2
4.6
31.2
9.6
40.6
162.4
39.4
158.6
63.4
62.6
58.7
0
0
60.9
3
(a) Estimate the factor effects. Plot the effect estimates on a normal probability scale.
(b) Identify a tentative model for this process. Fit the model and test for curvature.
(c) Plot the residuals from the model in part (b) versus the predicted resistivity. Is there any indication on
this plot of model inadequacy?
(d) Construct a normal probability plot of the residuals. Is there any reason to doubt the validity of the
normality assumption?
Stem1: 1,4
Stem 2: 2,4,8
Stem3: 2,4
Stem4: 0,1,6,8
Stem5: 0,1,2,3,9
Stem 6: 2,2
What’s the Min,Q1, Med,Q3,Max?
Chapter 2 Solutions
EBK FUNDAMENTALS OF BIOSTATISTICS
Ch. 2.6 - When is it appropriate to use the arithmetic mean...Ch. 2.6 - How does the geometric mean differ from the...Ch. 2.6 - What is the difference between the standard...Ch. 2.8 - What is a stem-and-leaf plot? How does it differ...Ch. 2.8 - Prob. B.2RECh. 2.8 - Consider the stem-and-leaf plot in Figure 2.6. Is...Ch. 2.8 - What is a box plot? What additional information...Ch. 2 - The data in Table 2.13 are a sample from a larger...Ch. 2 - The data in Table 2.13 are a sample from a larger...Ch. 2 - It is of clinical interest to know if the duration...
Ch. 2 - Suppose the scale for a data set is changed by...Ch. 2 - Suppose the scale for a data set is changed by...Ch. 2 - Suppose the scale for a data set is changed by...Ch. 2 - Suppose the scale for a data set is changed by...Ch. 2 - A man runs 1 mile approximately once per weekend....Ch. 2 - A man runs 1 mile approximately once per weekend....Ch. 2 - A man runs 1 mile approximately once per weekend....Ch. 2 - A man runs 1 mile approximately once per weekend....Ch. 2 - A man runs 1 mile approximately once per weekend....Ch. 2 - The data in Table 2.15 are a sample of cholesterol...Ch. 2 - The data in Table 2.15 are a sample of cholesterol...Ch. 2 - The data in Table 2.15 are a sample of cholesterol...Ch. 2 - The data in Table 2.15 are a sample of cholesterol...Ch. 2 - The data in Table 2.15 are a sample of cholesterol...Ch. 2 - In an experiment that examined the effect of body...Ch. 2 - In an experiment that examined the effect of body...Ch. 2 - Table 2.17 Format for FEV.DAT The data in Table...Ch. 2 - Forced expiratory volume (FEV) is an index of...Ch. 2 - Forced expiratory volume (FEV) is an index of...Ch. 2 - Prob. 26PCh. 2 - The food-frequency questionnaire (FFQ) is an...Ch. 2 - In Section 2.9, we described Data Set LEAD.DAT (at...Ch. 2 - In Section 2.9, we described Data Set LEAD.DAT (at...Ch. 2 - Activated-protein-C (APC) resistance is a serum...Ch. 2 - Activated-protein-C (APC) resistance is a serum...Ch. 2 - A study was conducted to demonstrate that soy...Ch. 2 - A study was conducted to demonstrate that soy...Ch. 2 - A study was conducted to demonstrate that soy...Ch. 2 - Prob. 38PCh. 2 - In Section 2.10, we described Data Set BONEDEN.DAT...Ch. 2 - What impression do you have of the relationship...Ch. 2 - In Section 2.10, we described Data Set BONEDEN.DAT...Ch. 2 - In Section 2.10, we described Data Set BONEDEN.DAT...Ch. 2 - Prob. 43PCh. 2 - Prob. 44PCh. 2 - Prob. 45PCh. 2 - Answer Problems 2.382.40 for BMD for the femoral...Ch. 2 - The Left Ventricular Mass lndex (LVMI) is a...Ch. 2 - Prob. 48PCh. 2 - Prob. 49PCh. 2 - The Left Ventricular Mass lndex (LVMI) is a...
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