EBK HUMAN ANATOMY & PHYSIOLOGY
16th Edition
ISBN: 8220100659836
Author: AMERMAN
Publisher: PEARSON
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Chapter 2, Problem 2CYU
Considering that water is a main component of the juices in the stomach and intestines, explain why digestion of lipids is more complicated than digestion of carbohydrates and proteins.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 2 Solutions
EBK HUMAN ANATOMY & PHYSIOLOGY
Ch. 2.1 - Prob. 1QCCh. 2.1 - What are atoms?Ch. 2.1 - How do the three types of subatomic particles...Ch. 2.1 - What is an element?Ch. 2.1 - 4. How are elements arranged in the periodic...Ch. 2.1 - What are isotopes?Ch. 2.1 - Prob. 1AWYLCh. 2.1 - The element lithium has an atomic number of 3 and...Ch. 2.2 - What is a mixture?Ch. 2.2 - 2. How do the three types of mixtures differ?
Ch. 2.2 - Prob. 3QCCh. 2.2 - What is an ionic bond?Ch. 2.2 - 5. How is an ionic bond formed?
Ch. 2.2 - 6. Explain how polar and nonpolar covalent bonds...Ch. 2.2 - What are hydrogen bonds? Why do hydrogen bonds...Ch. 2.2 - Which would be more reactive-an atom of fluorine...Ch. 2.2 - Would a molecule of hydrogen (H2) form hydrogen...Ch. 2.2 - Explain why the molecule Na2 does not exist in...Ch. 2.3 - Prob. 1QCCh. 2.3 - Prob. 2QCCh. 2.3 - How do endergonic and exergonic reactions differ?Ch. 2.3 - Prob. 4QCCh. 2.3 - What factors can influence the rate of a chemical...Ch. 2.3 - 6. What is an enzyme, and what does an enzyme do?
Ch. 2.3 - Prob. 1AWYLCh. 2.3 - Explain why most biological molecules are stable...Ch. 2.3 - 3. Many naturally occurring poisons function by...Ch. 2.4 - What are four properties of water that make it a...Ch. 2.4 - 2. Which molecules are likely to be hydrophilic?...Ch. 2.4 - 3. Define the terms acid and base.
Ch. 2.4 - What is the pH scale? Which pH values are...Ch. 2.4 - What is the effect of a buffer on a solution?Ch. 2.4 - What is a salt?Ch. 2.4 - 7. What does an electrolyte do in a solution?
Ch. 2.4 - Explain how the water surrounding a fetus in the...Ch. 2.4 - Prob. 2AWYLCh. 2.5 - 1. How do polymers and monomers differ?
Ch. 2.5 - 2.3. How do monosaccharides, disaccharides, and...Ch. 2.5 - 2. How do monosaccharides, disaccharides, and...Ch. 2.5 - How are two monosaccharides linked to form a...Ch. 2.5 - Prob. 5QCCh. 2.5 - 5. How do phospholipids and triglycerides differ?
Ch. 2.5 - What are steroids?Ch. 2.5 - Prob. 8QCCh. 2.5 - How are amino acids linked to form peptides and...Ch. 2.5 - What are the four levels of structural...Ch. 2.5 - 10. What are the components and roles of ATP?
Ch. 2.5 - 11. How do DNA and RNA differ?
Ch. 2.5 - 11. What are the three components of a...Ch. 2.5 - Which molecule would be the most soluble in water:...Ch. 2.5 - In Module 2.3, you learned that increasing...Ch. 2.5 - 3. How could a defect in a gene lead to a...Ch. 2 - Prob. 1CYRCh. 2 - Fill in the blanks: Isotopes are atoms with the...Ch. 2 - 3. Which of the following statements correctly...Ch. 2 - 4. Explain the difference between an ionic and a...Ch. 2 - Identify each of the following molecules or...Ch. 2 - What are hydrogen bonds, and how do they form?Ch. 2 - Prob. 7CYRCh. 2 - Prob. 8CYRCh. 2 - Which of the following would not result in an...Ch. 2 - 10. An enzyme is a:
a. biological catalyst that...Ch. 2 - Prob. 11CYRCh. 2 - With respect to their solubility in water,...Ch. 2 - Mark the following statements as true or false. If...Ch. 2 - A salt is: a. a metal cation bonded to a nonmetal...Ch. 2 - 15. Compare and contrast the structures of...Ch. 2 - 16. Mark the following statements as true or...Ch. 2 - 17. Why is it important for a protein to maintain...Ch. 2 - Which of the following is not part of a...Ch. 2 - 19. Mark the following properties as belonging to...Ch. 2 - Which of the following statements is/are true...Ch. 2 - 1. In certain types of radioactive decay, the...Ch. 2 - Considering that water is a main component of the...Ch. 2 - 3. Explain why monosaccharides are polar and fatty...Ch. 2 - 1. The polysaccharide cellulose is not digestible...Ch. 2 - Some claim that the pH of your blood can be...Ch. 2 - Prob. 3AYKCh. 2 - Prob. 5AYKCh. 2 - You have just dropped some phospholipids into...
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