(a) Interpretation: The degree of freedom analysis for the given process is to be calculated and all the manipulated input, output, and disturbance variables are to be identified. Concept introduction: For chemical processes, dynamic models consisting ordinary differential equations are derived through unsteady-state conservation laws. These laws generally include mass and energy balances. The process models generally include algebraic relationships which commence from thermodynamics , transport phenomena , chemical kinetics, and physical properties of the processes. Degree of freedom analysis of a process model ensures that its model equations are solvable. The expression to calculate the degree of freedom is: N F = N V − N E .........(1) Here, N F is the number of degree of freedom for the process model, N V is the total number of process variables, and N E is the total number of independent equations written for the process model.

Question

Develop a purification train for a facility where first process is a perfusion upstream bioreactors 500L producing low cell culture titer of approx. 0.5 g/L perfusing at 2 VVD over 30 days. The current facility has a secondary clarification process for the perfusate coming from the bioreactor. Secondary depth filtration clarification capacity of 200 L/m2. Identify the correct filter area, and system (pump) requirements for the process scale. Also identify optimal flowrates for flushing and processing, total process time, buffer volumes required. Assume 10 L/m2 holdup of the depth filters identify the size of the tank required to collect the filtrate. Average yield of overall clarification is 80% estimate the titer in the clarified pool.

Answer 1

Question

Chapter 2, Problem 2.7E

Interpretation Introduction

(a)

Interpretation:

The degree of freedom analysis for the given process is to be calculated and all the manipulated input, output, and disturbance variables are to be identified.

Concept introduction:

For chemical processes, dynamic models consisting ordinary differential equations are derived through unsteady-state conservation laws. These laws generally include mass and energy balances.

The process models generally include algebraic relationships which commence from thermodynamics, transport phenomena, chemical kinetics, and physical properties of the processes.

Degree of freedom analysis of a process model ensures that its model equations are solvable. The expression to calculate the degree of freedom is:

NF=NV−NE .........(1)

Here, NF is the number of degree of freedom for the process model, NV is the total number of process variables, and NE is the total number of independent equations written for the process model.

Interpretation Introduction

(b)

Interpretation:

The degree of freedom analysis for the given process is to be calculated and all the manipulated input, output, and disturbance variables are to be identified.

Concept introduction:

For chemical processes, dynamic models consisting ordinary differential equations are derived through unsteady-state conservation laws. These laws generally include mass and energy balances.

The process models generally include algebraic relationships which commence from thermodynamics, transport phenomena, chemical kinetics, and physical properties of the processes.

Degree of freedom analysis of a process model ensures that its model equations are solvable. The expression to calculate the degree of freedom is:

NF=NV−NE .........(1)

Here, NF is the number of degree of freedom for the process model, NV is the total number of process variables, and NE is the total number of independent equations written for the process model.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Students have asked these similar questions

Develop a purification train for a facility where first process is a perfusion upstream bioreactors 500L producing low cell culture titer of approx. 0.5 g/L perfusing at 2 VVD over 30 days. The current facility has a secondary clarification process for the perfusate coming from the bioreactor. Secondary depth filtration clarification capacity of 200 L/m2. Identify the correct filter area, and system (pump) requirements for the process scale. Also identify optimal flowrates for flushing and processing, total process time, buffer volumes required. Assume 10 L/m2 holdup of the depth filters identify the size of the tank required to collect the filtrate. Average yield of overall clarification is 80% estimate the titer in the clarified pool.

Bioprocessing/ Protein isolation and purification. Develop a purification train for a facility where first process is a perfusion upstream bioreactors 500L producing low cell culture titer of approx. 0.5 g/L perfusing at 2 VVD over 30 days. The current facility has a secondary clarification process for the perfusate coming from the bioreactor. Secondary depth filtration clarification capacity of 200 L/m2. Identify the correct filter area, and system (pump) requirements for the process scale. Also identify optimal flowrates for flushing and processing, total process time, buffer volumes required. Assume 10 L/m2 holdup of the depth filters identify the size of the tank required to collect the filtrate. Average yield of overall clarification is 80% estimate the titer in the clarified pool.

solve for both a stripper and absorber. take the equilibrium data given to just be a y=x line