SAPLINGPLUS FOR PRINCIPLES OF BIOCHEMIS
SAPLINGPLUS FOR PRINCIPLES OF BIOCHEMIS
7th Edition
ISBN: 9781319424572
Author: nelson
Publisher: MAC HIGHER
Question
Book Icon
Chapter 2, Problem 1P
Summary Introduction

To determine: Whether the ionic interaction between the enzyme and substrate  are stronger or weaker if the ATP-binding site of an enzyme is buried in the interior of the enzyme in a hydrophobic environment than the same interaction on the surface of the enzyme when exposed to water.

Introduction:

The ionic bonding results from the interaction of ionic species. The ionic bonding forms the hydrophilic compounds. The hydrophilic compounds are more likely to be dissolved in water than the hydrophobic compounds. There is binding between the enzyme and substrate.

Expert Solution & Answer
Check Mark

Explanation of Solution

Explanation:

The ionic forces are proportional to an inverse of dielectric constant. The dielectric constant (εr) of water is 78.54 at 25 °C. This value accounts for less strong forces of attraction. The ionic forces between substrate and enzyme will be weaker if they both are present in water. This will affect the binding of enzyme to substrate.

The inner portion of protein is hydrophobic and the dielectric constant is lower in the hydrophobic regions. The ionic forces of attraction between enzyme and substrate in core of protein will be stronger and the substrate and enzyme will bind to each other effectively.

Therefore, the ionic forces of attraction will be stronger, if the ATP binding site present in the core of protein than the forces of attraction, if the binding site is exposed to water.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!
Students have asked these similar questions
Biochemistry Assuming 2.5 molecules of ATP per oxidation of NADH/(H+) and 1.5molecules of ATP per oxidation of FADH2, how many ATP are produced per molecule of pyruvate? Please help. Thank you
1. How would you explain the term ‘good food’? 2. How would you define Nutrition? 3. Nutrients are generally categorised into two forms. Discuss.
Biochemistry Question. Please help solve. Thank you! Based upon knowledge of oxidation of bioorganic compounds and howmuch energy is released during their oxidation, rank the following, from most to least, with respect to how much energy would be produced from each during their oxidation. Explain your placement for each one.
Knowledge Booster
Background pattern image
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman
Text book image
Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman
Text book image
Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY
Text book image
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON