Human Anatomy
Human Anatomy
9th Edition
ISBN: 9780135168059
Author: Marieb, Elaine Nicpon, Brady, Patricia, Mallatt, Jon
Publisher: Pearson Education, Inc.,
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Chapter 2, Problem 1CRCAQ
Summary Introduction

To review:

The relation between the process of aging and low weight.

Introduction:

Aging is characterized by certain structural as well as functional alterations that begin accumulating in an individual as time passes. It is a complex process that is explained by two different theories, namely mitochondrial theory and genetic theory. These theories support the idea that aging results due to a build up of free radicals and shortening of telomere length.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0  Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present.  Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
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Chapter 2 Solutions

Human Anatomy

Ch. 2 - How does the appearance of extended chromatin...Ch. 2 - In which phase of the cell life cycle does the...Ch. 2 - Prob. 13CYUCh. 2 - Which cellular structures would be abundant in...Ch. 2 - Which organelles would be abundant in cells that...Ch. 2 - According to which aging theory presented here can...Ch. 2 - The endocytotic process in which particulate...Ch. 2 - The nuclear substance composed of histone proteins...Ch. 2 - Final preparations for cell division are made...Ch. 2 - Prob. 4RQCh. 2 - Identify the cell structure or organelle described...Ch. 2 - Prob. 6RQCh. 2 - The trans face of the Golgi apparatus (a) is its...Ch. 2 - Prob. 8RQCh. 2 - Name the appropriate stage of mitosis (prophase,...Ch. 2 - Name the cytoskeletal element (actin...Ch. 2 - Prob. 11RQCh. 2 - Which of these processes involves specific...Ch. 2 - List all the cytoplasmic organelles that are...Ch. 2 - Martin missed a point on his anatomy test because...Ch. 2 - In this chapter, we claimed that mitochondria are...Ch. 2 - Define chromosome, then compare the arrangement of...Ch. 2 - Prob. 17RQCh. 2 - Use the analogy of the cell as a manufacturing...Ch. 2 - Prob. 1CRCAQCh. 2 - Kareem had a nervous habit of chewing on the inner...Ch. 2 - The normal function of one tumor-suppressor gene...Ch. 2 - In their anatomy labs, many students are exposed...Ch. 2 - The sedative phenobarbital is a lipid-soluble...Ch. 2 - The drug vinblastine is used in cancer therapy to...Ch. 2 - Use the word roots listed at the start of Chapter...
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