Human Anatomy
9th Edition
ISBN: 9780135168059
Author: Marieb, Elaine Nicpon, Brady, Patricia, Mallatt, Jon
Publisher: Pearson Education, Inc.,
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Textbook Question
Chapter 2, Problem 14RQ
Martin missed a point on his anatomy test because he thought nucleus and nucleolus were the same word and the same structure. Distinguish the nucleus from the nucleolus.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 2 Solutions
Human Anatomy
Ch. 2 - What are the three general regions of a cell?Ch. 2 - What types of macromolecules compose the plasma...Ch. 2 - By what process does water enter and leave the...Ch. 2 - Which transport process carries large...Ch. 2 - Which cellular organelles are involved with...Ch. 2 - Which organelle produces the energy needed for...Ch. 2 - Which organelle would be prevalent in a cell that...Ch. 2 - Which cytoskeletal element functions to resist...Ch. 2 - What does the nucleolus produce?Ch. 2 - Which cytoplasmic organelle is continuous with the...
Ch. 2 - How does the appearance of extended chromatin...Ch. 2 - In which phase of the cell life cycle does the...Ch. 2 - Prob. 13CYUCh. 2 - Which cellular structures would be abundant in...Ch. 2 - Which organelles would be abundant in cells that...Ch. 2 - According to which aging theory presented here can...Ch. 2 - The endocytotic process in which particulate...Ch. 2 - The nuclear substance composed of histone proteins...Ch. 2 - Final preparations for cell division are made...Ch. 2 - Prob. 4RQCh. 2 - Identify the cell structure or organelle described...Ch. 2 - Prob. 6RQCh. 2 - The trans face of the Golgi apparatus (a) is its...Ch. 2 - Prob. 8RQCh. 2 - Name the appropriate stage of mitosis (prophase,...Ch. 2 - Name the cytoskeletal element (actin...Ch. 2 - Prob. 11RQCh. 2 - Which of these processes involves specific...Ch. 2 - List all the cytoplasmic organelles that are...Ch. 2 - Martin missed a point on his anatomy test because...Ch. 2 - In this chapter, we claimed that mitochondria are...Ch. 2 - Define chromosome, then compare the arrangement of...Ch. 2 - Prob. 17RQCh. 2 - Use the analogy of the cell as a manufacturing...Ch. 2 - Prob. 1CRCAQCh. 2 - Kareem had a nervous habit of chewing on the inner...Ch. 2 - The normal function of one tumor-suppressor gene...Ch. 2 - In their anatomy labs, many students are exposed...Ch. 2 - The sedative phenobarbital is a lipid-soluble...Ch. 2 - The drug vinblastine is used in cancer therapy to...Ch. 2 - Use the word roots listed at the start of Chapter...
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