Laboratory Manual for Human Anatomy & Physiology (Cat Version)
4th Edition
ISBN: 9781259864612
Author: Martin
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 2, Problem 1.1A
Match the body cavities in column A with the organs contained in the cavities in Column B. Place the letter of your choice in the space provided.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 2 Solutions
Laboratory Manual for Human Anatomy & Physiology (Cat Version)
Ch. 2 - The basis for communication in anatomy and...Ch. 2 - Which of the following is not a body cavity?...Ch. 2 - The pericardium is associated with the lung....Ch. 2 - The ____________ plane divides the body into left...Ch. 2 - The abdominopelvic cavity can be subdivided into...Ch. 2 - The larynx is part of the __________ system....Ch. 2 - The epigastric region is a portion of the _______...Ch. 2 - In the posterior view, the cubital region is...Ch. 2 - The brachial surface region pertains to the wrist....Ch. 2 - A frontal plane divides the body into anterior and...
Ch. 2 - Match the body cavities in column A with the...Ch. 2 - FIGURE 2.10 Label body cavities 1-5. Add a...Ch. 2 - FIGURE 2.11 Label the specific serous membranes...Ch. 2 - the organ systems in column A with the principal...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - Indicate whether each of the following sentences...Ch. 2 - FIGURE 2.12 Label the planes of the sectioned...Ch. 2 - Figure 2.13 Label the indicated body surface...Ch. 2 - Examine the letters A, B, and C indicated on...
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