Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Textbook Question
Chapter 19.7, Problem 12CC
If plasma creatinine = 1.8 mg/100 mL plasma, urine creatinine = 1.5 mg/mL urine, and urine volume is 1100 mL 24 hours, what is the creatinine clearance? What is GFR?
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If the rate of urine formation is 2 ml/min, the urine inulin concentration is 25 mg/ml, and the plasma inulin concentration 0.5 mg/ml,
then the GFR is
6.25 mL/min
None of the choices are correct.
(c) 0.04 mL/min
D) 100 mL/min
E) more data is needed to calculate the GFR
Calculate net filtration pressure given the following values: glomerular hydrostatic pressure = 50 mm Hg, blood colloid osmotic pressure = 25 mm Hg, capsular hydrostatic pressure = 20 Hg.
The normal glomerular filtration rate in the following results is:
1) 2 ml/min,
2) 125 ml/min
3) 800 ml/min
4) 1,200 ml/min
Chapter 19 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 19.1 - Ion regulation is a key feature of kidney...Ch. 19.1 - What happens to the force of cardiac contraction...Ch. 19.2 - If net filtration out of glomerular capillaries...Ch. 19.2 - If net reabsorption into peritubular capillaries...Ch. 19.3 - Name one way in which filtration and secretion are...Ch. 19.3 - A water molecule enters the renal corpuscle from...Ch. 19.3 - Prob. 7CCCh. 19.4 - Why is the osmotic pressure of plasma in efferent...Ch. 19.4 - If a hypertensive persons blood pressure is...Ch. 19.4 - If systemic blood pressure remains constant but...
Ch. 19.4 - A person with cirrhosis of the liver has...Ch. 19.7 - If plasma creatinine = 1.8 mg/100 mL plasma, urine...Ch. 19 - List and explain the significance of the five...Ch. 19 - List and explain the six major kidney functions.Ch. 19 - At any given time, what percentage of cardiac...Ch. 19 - Prob. 4RQCh. 19 - Arrange the following structures in the order that...Ch. 19 - Name the three filtration barriers that solutes...Ch. 19 - Prob. 7RQCh. 19 - What does the abbreviation GFR stand for? What is...Ch. 19 - Identify the following structures, then explain...Ch. 19 - In which segment of the nephron does most...Ch. 19 - Match each of the following substances with its...Ch. 19 - Prob. 12RQCh. 19 - Prob. 13RQCh. 19 - Prob. 14RQCh. 19 - Map the following terms. You may add terms if you...Ch. 19 - Define, compare, and contrast the items in the...Ch. 19 - What are the advantages of a kidney that filters a...Ch. 19 - Prob. 18RQCh. 19 - Diagram the micturition reflex. How is this reflex...Ch. 19 - Antimuscarinic drugs are the accepted treatment...Ch. 19 - Draw a section of renal tubule epithelium showing...Ch. 19 - Prob. 22RQCh. 19 - Read the box on hemodialysis on p. 603 and see if...Ch. 19 - Graphing question: You are given a chemical Z and...Ch. 19 - Prob. 25RQCh. 19 - Prob. 26RQCh. 19 - Dwight was competing for a spot on the Olympic...Ch. 19 - You are a physiologist taking part in an...Ch. 19 - If 140 liters of plasma are filtered in a day, and...
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- A urinalysis reveals that the patients urine contains glucose, hemoglobin, and white blood cells (pus). Are any of these substances abnormal in urine? Explain.arrow_forwardGiven: For urea, the rate of excretion equals to the GFR times the urea concentration in plasma. (A) If the urea concentration in plasma is 4.5 mmol/l, what GFR (in l/day) would correspond to an excretion rate of 450 mmol/day. (B) If the urea clearance is 70 ml/min and the GFR is 125 ml/min, what fraction of urea is being reabsorbed. (answer A and B)arrow_forwardIf a patient collects a 24 hour urine specimen with a volume of 1500 mL, and the patient's serum Creatinine is 5 mg/dl, and the urine creatinine is 100 mg/dl, then what is the creatinine clearance in ml/min?arrow_forward
- Explain what GFR 25 mL/min means?arrow_forwardGiven: The concentration of glucose in the blood is 1 mg/mL. This person then decides to go for a brisk run, which doubles GFR. a. What effect will this have on the amount of inulin and glucose present in their urine? Why? (answer a )arrow_forwardWhat is the relationship between plasma creatinine concentration and glomerular filtration rate?arrow_forward
- How to calculate glomerular filtration rate given this information: molecular weight of drug, total plasma concentration, and percent of drug that is protein plasma bound?arrow_forwardTable 3. Serum creatinine values at admission and after 12h Admission +12h SCR(mg/dL) 1.55 1.42 Using the “MDRD” (Modification of Diet in Renal Disease) equation for estimating glomerularfiltration, provided below, and the data available in the above table, calculate the patient's (a 34 year old white male) estimated glomerularfiltration rate (eGFR) at admission and 12h after admission.MDRD GFR Equation (mL/min/1.73 m2)= 175 × (Scr)-1.154 × (Age)-0.203 × (0.742 if female) × (1.212 if African American)Based on your calculated values, state whether LF’s function is normal or abnormal?Previous research suggests that patients with asthma have an increased risk for chronic kidneydisease, but the mechanisms underlying this increased risk are poorly understood. Propose one potential mechanism by which asthma might impair kidney function, and discuss how this dysfunction may impair thebody’s ability to respond to respiratory alkalosisarrow_forwardEstimate the GFR in a 48-year-old woman who weighs 60 kg using the Cockcroft-Gault equation (in mL/min). Her serum creatinine level is 2.5 mg/dL (round to the next full number; no decimal places). Please help with this question and show the work. Thanksarrow_forward
- Urine creatinine: 180 mg/dL . Plasma creatinine: 2.3 mg/dL . Urine output: 1.6 mL/mi Creatinine Clearance (C) = (Urine Creatinine × Urine Flow Rate) / Plasma Creatinine What is Carrow_forwardWhen performing a Cockroft-Gault calculation to estimate GFR, why must renal function be stable for the calculation be valid? Why is the Cockroft-Gault calculation invalid for patients receiving dialysis? Which two labs are required to stage CKD GFR and categorize albumenuria?arrow_forwardWhat happens to blood concentration of plasma proteins in an individual with renal disease that results in either (a) damage to the filtration membrane or (b) decreased filtration at the filtration membrane?arrow_forward
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