Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Chapter 19.3, Problem 4AYP
List the possible causative agents, modes of transmission, virulence factors, diagnostic techniques, and prevention/treatment for the “Highlight Disease,” pharyngitis.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 19 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 19.1 - Draw or describe the anatomical features of the...Ch. 19.1 - Prob. 2AYPCh. 19.2 - List the types of normal biota presently known to...Ch. 19.2 - Prob. 1MMCh. 19.3 - List the possible causative agents, modes of...Ch. 19.3 - Identify the most dangerous cause of pharyngitis...Ch. 19.3 - Prob. 6AYPCh. 19.3 - Prob. 1NPCh. 19.3 - Prob. 2NPCh. 19.3 - Prob. 3NP
Ch. 19.4 - Prob. 7AYPCh. 19.4 - Compare and contrast antigenic drift and antigenic...Ch. 19.4 - Prob. 9AYPCh. 19.5 - Prob. 10AYPCh. 19.5 - Prob. 11AYPCh. 19.5 - Prob. 12AYPCh. 19.5 - Prob. 2MMCh. 19.5 - Prob. 4NPCh. 19 - Which of the following organisms is most...Ch. 19 - Prob. 2QCh. 19 - It has recently been established that the lower...Ch. 19 - Which of these microbes has an unusual, waxy, wall...Ch. 19 - What cell structure of Streptococcus pneumoniae...Ch. 19 - Prob. 6QCh. 19 - The betahemolysis of blood agar observed with...Ch. 19 - Would you expect the microbiome in the lung to be...Ch. 19 - In some diseases and outbreaks of respiratory...Ch. 19 - Prob. 10QCh. 19 - Prob. 11QCh. 19 - Prob. 12QCh. 19 - Which of the following infections often has/have a...Ch. 19 - Outline how a progression from influenza infection...Ch. 19 - Prob. 15QCh. 19 - Prob. 16QCh. 19 - Prob. 17QCh. 19 - Conducting your own research, describe the total...Ch. 19 - Watchful waiting is the recommended response to...Ch. 19 - Prob. 20QCh. 19 - Prob. 21QCh. 19 - From chapter 2, figure 2.18b. Although there are...
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