EBK HUMAN ANATOMY
EBK HUMAN ANATOMY
8th Edition
ISBN: 9780100799554
Author: Martini
Publisher: YUZU
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Chapter 19, Problem 7RFT
Summary Introduction

To review:

Match the term oxyphil with the most closely related description given below:

Unknown function

Stimulates milk production

Regulated by hormones

Pineal gland

Norepinephrine release

Decreases water loss

Lymphocyte maturation

Stimulates estrogen secretion

Produces releasing hormone

Viscous fluid with stored hormones

Introduction:

The parathyroid glands are four in number and are embedded in the connective tissue of thyroid gland on its posterior surface. Two types of cells are present in the parathyroid gland, namely oxyphil cells and parathyroid cells.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
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