Synthesis of the given compound Darvon, starting with ethyl phenyl ketone is to be outlined. Concept introduction: Grignard reagent reactions with carbonyl groups are treated as acid–base reactions. The reaction of Grignard reagents with carbonyl groups yields secondary and tertiary alcohols. These reactions are two-step reactions. In the first step, nucleophilic addition of carbonyl group takes place because Grignard reagent, being nucleophilic, uses its lone pair of electrons to form a bond with a carbon atom. This results in the formation of an alkoxide ion which remains associated with M g 2 + and X − . In the second step, addition of aqueous HX causes the protonation of the alkoxide ion, which leads to the formation of the alcohol and M g X 2 . Mannich reaction: Carbonyl groups capable of forming enol react with primary or secondary amine and formaldehyde to form a β -amino carbonyl compounds known as Mannich base. Alcohols react with acetic anhydride to form esters via nucleophilic substitution reaction.

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Answer 1

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 19, Problem 50P

Interpretation Introduction

Interpretation:

Synthesis of the given compound Darvon, starting with ethyl phenyl ketone is to be outlined.

Concept introduction:

Grignard reagent reactions with carbonyl groups are treated as acid–base reactions.

The reaction of Grignard reagents with carbonyl groups yields secondary and tertiary alcohols. These reactions are two-step reactions. In the first step, nucleophilic addition of carbonyl group takes place because Grignard reagent, being nucleophilic, uses its lone pair of electrons to form a bond with a carbon atom. This results in the formation of an alkoxide ion which remains associated with Mg2+ and X−.

In the second step, addition of aqueous HX causes the protonation of the alkoxide ion, which leads to the formation of the alcohol and MgX2.

Mannich reaction: Carbonyl groups capable of forming enol react with primary or secondary amine and formaldehyde to form a β-amino carbonyl compounds known as Mannich base.

Alcohols react with acetic anhydride to form esters via nucleophilic substitution reaction.

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1. Problem Set 3b Chem 141 For each of the following compounds draw the BEST Lewis Structure then sketch the molecule (showing bond angles). Identify (i) electron group geometry (ii) shape around EACH central atom (iii) whether the molecule is polar or non-polar (iv) (a) SeF4 Best Lewis Structure e group arrangement:_ shape/molecular geometry: polarity: (b) AsOBr3 Best Lewis Structure e group arrangement:_ shape/molecular geometry: polarity: Sketch (with angles): Sketch (with angles):

Answer 2

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 19, Problem 50P

Interpretation Introduction

Interpretation:

Synthesis of the given compound Darvon, starting with ethyl phenyl ketone is to be outlined.

Concept introduction:

Grignard reagent reactions with carbonyl groups are treated as acid–base reactions.

The reaction of Grignard reagents with carbonyl groups yields secondary and tertiary alcohols. These reactions are two-step reactions. In the first step, nucleophilic addition of carbonyl group takes place because Grignard reagent, being nucleophilic, uses its lone pair of electrons to form a bond with a carbon atom. This results in the formation of an alkoxide ion which remains associated with Mg2+ and X−.

In the second step, addition of aqueous HX causes the protonation of the alkoxide ion, which leads to the formation of the alcohol and MgX2.

Mannich reaction: Carbonyl groups capable of forming enol react with primary or secondary amine and formaldehyde to form a β-amino carbonyl compounds known as Mannich base.

Alcohols react with acetic anhydride to form esters via nucleophilic substitution reaction.

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Answer 3

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 19, Problem 50P

Interpretation Introduction

Interpretation:

Synthesis of the given compound Darvon, starting with ethyl phenyl ketone is to be outlined.

Concept introduction:

Grignard reagent reactions with carbonyl groups are treated as acid–base reactions.

The reaction of Grignard reagents with carbonyl groups yields secondary and tertiary alcohols. These reactions are two-step reactions. In the first step, nucleophilic addition of carbonyl group takes place because Grignard reagent, being nucleophilic, uses its lone pair of electrons to form a bond with a carbon atom. This results in the formation of an alkoxide ion which remains associated with Mg2+ and X−.

In the second step, addition of aqueous HX causes the protonation of the alkoxide ion, which leads to the formation of the alcohol and MgX2.

Mannich reaction: Carbonyl groups capable of forming enol react with primary or secondary amine and formaldehyde to form a β-amino carbonyl compounds known as Mannich base.

Alcohols react with acetic anhydride to form esters via nucleophilic substitution reaction.

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Check out a sample textbook solution

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Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 19, Problem 50P

Interpretation Introduction