EBK HUMAN PHYSIOLOGY
8th Edition
ISBN: 9780134704227
Author: Silverthorn
Publisher: YUZU
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Textbook Question
Chapter 19, Problem 28RQ
You are a physiologist taking part in an archeological expedition to search for Atlantis. One of the deep-sea submersibles has come back with a mermaid, and you are taking a series of samples from her. You have determined that her GFR is 250 mL/min and that her kidneys reabsorb glucose with a transport maximum of 50 mg/min. What is her renal threshold for glucose? When her plasma concentration of glucose is 15 mg/mL, what is its glucose clearance?
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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.
b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake?
Options:
A. Dose; Increase dose
B. Dose; Decrease dose
C. Dose; Do not change dose
D. Interval; Increase the interval between doses (give the drug less frequently)
E. Interval; Decrease the interval between doses (give the drug more frequently)
F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
Chapter 19 Solutions
EBK HUMAN PHYSIOLOGY
Ch. 19.1 - Ion regulation is a key feature of kidney...Ch. 19.1 - What happens to the force of cardiac contraction...Ch. 19.2 - If net filtration out of glomerular capillaries...Ch. 19.2 - If net reabsorption into peritubular capillaries...Ch. 19.3 - Name one way in which filtration and secretion are...Ch. 19.3 - A water molecule enters the renal corpuscle from...Ch. 19.3 - Prob. 7CCCh. 19.4 - Why is the osmotic pressure of plasma in efferent...Ch. 19.4 - If a hypertensive persons blood pressure is...Ch. 19.4 - If systemic blood pressure remains constant but...
Ch. 19.4 - A person with cirrhosis of the liver has...Ch. 19.7 - If plasma creatinine = 1.8 mg/100 mL plasma, urine...Ch. 19 - List and explain the significance of the five...Ch. 19 - List and explain the six major kidney functions.Ch. 19 - At any given time, what percentage of cardiac...Ch. 19 - Prob. 4RQCh. 19 - Arrange the following structures in the order that...Ch. 19 - Name the three filtration barriers that solutes...Ch. 19 - Prob. 7RQCh. 19 - What does the abbreviation GFR stand for? What is...Ch. 19 - Identify the following structures, then explain...Ch. 19 - In which segment of the nephron does most...Ch. 19 - Match each of the following substances with its...Ch. 19 - Prob. 12RQCh. 19 - Prob. 13RQCh. 19 - Prob. 14RQCh. 19 - Map the following terms. You may add terms if you...Ch. 19 - Define, compare, and contrast the items in the...Ch. 19 - What are the advantages of a kidney that filters a...Ch. 19 - Prob. 18RQCh. 19 - Diagram the micturition reflex. How is this reflex...Ch. 19 - Antimuscarinic drugs are the accepted treatment...Ch. 19 - Draw a section of renal tubule epithelium showing...Ch. 19 - Prob. 22RQCh. 19 - Read the box on hemodialysis on p. 603 and see if...Ch. 19 - Graphing question: You are given a chemical Z and...Ch. 19 - Prob. 25RQCh. 19 - Prob. 26RQCh. 19 - Dwight was competing for a spot on the Olympic...Ch. 19 - You are a physiologist taking part in an...Ch. 19 - If 140 liters of plasma are filtered in a day, and...
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