ORGANIC CHEMISTRY-ACCESS
ORGANIC CHEMISTRY-ACCESS
6th Edition
ISBN: 9781260475586
Author: SMITH
Publisher: MCG
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Chapter 18.5, Problem 11P
Interpretation Introduction

(a)

Interpretation: The reagents that are needed to convert the given compound into acetophenone (C6H5COCH3) are to be predicted.

Concept introduction: The acylation of aromatic rings is facilitated by Friedel-Crafts acylation reaction. In this reaction, acyl chlorides are used as acylating agents, and Lewis acids like AlCl3 are used as catalyst.

Interpretation Introduction

(b)

Interpretation: The reagents that are needed to convert the given compound into acetophenone (C6H5COCH3) are to be predicted.

Concept introduction: Lithium dialkylcuprate yields ketone, when it is treated with an acyl chloride, followed by hydrolysis. This reagent is obtained from the reaction of organolithium reagent with cuprous iodide, CuI.

2R'Li+CuIR'2CuLi+LiI

Interpretation Introduction

(c)

Interpretation: The reagents that are needed to convert the given compound into acetophenone (C6H5COCH3) are to be predicted.

Concept introduction: The oxymercuration reaction is an electrophilic addition reaction that converts an alkene into an alcohol and an alkyne into a ketone. The reagents required for this reaction are [1]Hg(OAc)2;[2]H2O,Et2OorTHF.

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