GEN COMBO LOOSELEAF MICROBIOLOGY:A SYSTEMS APPROACH; CONNECT ACCESS CARD
5th Edition
ISBN: 9781260149364
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 18.4, Problem 11AYP
Summary Introduction
To enlist:
The natural defense present in the eye.
Concept introduction:
The eye is one of the crucial and complex organs of the body system. It consists of different types of tissues and has the ability to process the visual details. The exposed surfaces of the eye include the conjunctiva and cornea. Eye gives an individual the ability to visualize the things.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 18 Solutions
GEN COMBO LOOSELEAF MICROBIOLOGY:A SYSTEMS APPROACH; CONNECT ACCESS CARD
Ch. 18.1 - Describe the important anatomical features of the...Ch. 18.1 - Prob. 2AYPCh. 18.2 - Prob. 3AYPCh. 18.3 - Prob. 4AYPCh. 18.3 - Prob. 5AYPCh. 18.3 - Prob. 6AYPCh. 18.3 - Prob. 7AYPCh. 18.3 - Prob. 8AYPCh. 18.3 - Prob. 9AYPCh. 18.4 - Prob. 10AYP
Ch. 18.4 - Prob. 11AYPCh. 18.5 - List the types of normal biota presently known to...Ch. 18.6 - Prob. 13AYPCh. 18.6 - Prob. 14AYPCh. 18 - Prob. 1MCQCh. 18 - Prob. 2MCQCh. 18 - Which of the following is probably the most...Ch. 18 - Prob. 4MCQCh. 18 - Prob. 5MCQCh. 18 - Prob. 6MCQCh. 18 - Prob. 7MCQCh. 18 - Prob. 8MCQCh. 18 - Prob. 9MCQCh. 18 - Prob. 10MCQCh. 18 - Prob. 11TFCh. 18 - Prob. 12TFCh. 18 - Prob. 13TFCh. 18 - Prob. 14TFCh. 18 - Prob. 15TFCh. 18 - Prob. 1CTQCh. 18 - Prob. 2CTQCh. 18 - a. Conduct additional research, and discuss...Ch. 18 - Prob. 4CTQCh. 18 - Prob. 5CTQCh. 18 - Prob. 1VCCh. 18 - Prob. 1CM
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