ANATOMY+PHYSIOLOGY >CUSTOM<
9th Edition
ISBN: 2818440061721
Author: SALADIN
Publisher: MCG/CREATE
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Chapter 18.2, Problem 7AYLO
Summary Introduction
To discuss:
The homeostatic regulation of erythropoiesis and the origins and role of erythropoietin.
Introduction:
Erythropoiesis is the formation of red blood cells, and it occurs in the red bone marrow in four different stages: decrease in cell size, increase in cell number, increase in hemoglobin synthesis, shedding of nuclear material along with other organelles. A new supply of RBCs by erythropoiesis is needed to maintain a constant RBC number in the blood as RBCs have a lifespan of 120 days and die at the end of this period.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
Chapter 18 Solutions
ANATOMY+PHYSIOLOGY >CUSTOM<
Ch. 18.1 - Identify at least two each of the transport,...Ch. 18.1 - Prob. 2BYGOCh. 18.1 - List the three major classes of plasma proteins....Ch. 18.1 - Prob. 4BYGOCh. 18.1 - Prob. 5BYGOCh. 18.1 - Prob. 1AYLOCh. 18.1 - Prob. 2AYLOCh. 18.1 - Prob. 3AYLOCh. 18.1 - Prob. 4AYLOCh. 18.1 - Prob. 5AYLO
Ch. 18.1 - Prob. 6AYLOCh. 18.1 - Prob. 7AYLOCh. 18.2 - Describe the size, shapte, and contents of an...Ch. 18.2 - Prob. 7BYGOCh. 18.2 - Prob. 8BYGOCh. 18.2 - Prob. 9BYGOCh. 18.2 - Prob. 10BYGOCh. 18.2 - Prob. 11BYGOCh. 18.2 - Prob. 12BYGOCh. 18.2 - Prob. 1AYLOCh. 18.2 - Prob. 2AYLOCh. 18.2 - Prob. 3AYLOCh. 18.2 - Three ways of quantifying the RBCs and hemoglobin...Ch. 18.2 - Prob. 5AYLOCh. 18.2 - Prob. 6AYLOCh. 18.2 - Prob. 7AYLOCh. 18.2 - Prob. 8AYLOCh. 18.2 - Prob. 9AYLOCh. 18.2 - Prob. 10AYLOCh. 18.2 - Causes and effects of hemoglobin deficiencies and...Ch. 18.3 - Prob. 13BYGOCh. 18.3 - Prob. 14BYGOCh. 18.3 - Prob. 15BYGOCh. 18.3 - Prob. 16BYGOCh. 18.3 - Prob. 1AYLOCh. 18.3 - Prob. 2AYLOCh. 18.3 - Prob. 3AYLOCh. 18.3 - Prob. 4AYLOCh. 18.3 - Prob. 5AYLOCh. 18.3 - Prob. 6AYLOCh. 18.3 - Hemolytic disease of the newborn; why it seldom...Ch. 18.4 - Prob. 17BYGOCh. 18.4 - Prob. 18BYGOCh. 18.4 - Prob. 19BYGOCh. 18.4 - Prob. 20BYGOCh. 18.4 - Prob. 21BYGOCh. 18.4 - Prob. 1AYLOCh. 18.4 - Prob. 2AYLOCh. 18.4 - Prob. 3AYLOCh. 18.4 - Prob. 4AYLOCh. 18.4 - Prob. 5AYLOCh. 18.4 - Prob. 6AYLOCh. 18.4 - Prob. 7AYLOCh. 18.5 - Prob. 22BYGOCh. 18.5 - Prob. 23BYGOCh. 18.5 - Prob. 24BYGOCh. 18.5 - Prob. 25BYGOCh. 18.5 - Prob. 26BYGOCh. 18.5 - Prob. 1AYLOCh. 18.5 - Prob. 2AYLOCh. 18.5 - Prob. 3AYLOCh. 18.5 - Prob. 4AYLOCh. 18.5 - Prob. 5AYLOCh. 18.5 - Prob. 6AYLOCh. 18.5 - Prob. 7AYLOCh. 18.5 - Prob. 8AYLOCh. 18.5 - Prob. 9AYLOCh. 18.5 - Prob. 10AYLOCh. 18.5 - Prob. 11AYLOCh. 18.5 - Terms for unwanted or inappropriate clotting in a...Ch. 18.5 - Prob. 13AYLOCh. 18 - Antibodies belong to a class of plasma proteins...Ch. 18 - Prob. 2TYRCh. 18 - Prob. 3TYRCh. 18 - Prob. 4TYRCh. 18 - Prob. 5TYRCh. 18 - Prob. 6TYRCh. 18 - Prob. 7TYRCh. 18 - Prob. 8TYRCh. 18 - Prob. 9TYRCh. 18 - Prob. 10TYRCh. 18 - Prob. 11TYRCh. 18 - Prob. 12TYRCh. 18 - Prob. 13TYRCh. 18 - Prob. 14TYRCh. 18 - Prob. 15TYRCh. 18 - Prob. 16TYRCh. 18 - Prob. 17TYRCh. 18 - Prob. 18TYRCh. 18 - Prob. 19TYRCh. 18 - Prob. 20TYRCh. 18 - Prob. 1BYMVCh. 18 - Prob. 2BYMVCh. 18 - Prob. 3BYMVCh. 18 - Prob. 4BYMVCh. 18 - Prob. 5BYMVCh. 18 - Prob. 6BYMVCh. 18 - Prob. 7BYMVCh. 18 - Prob. 8BYMVCh. 18 - Prob. 9BYMVCh. 18 - Prob. 10BYMVCh. 18 - Prob. 1WWTSCh. 18 - Prob. 2WWTSCh. 18 - Prob. 3WWTSCh. 18 - Prob. 4WWTSCh. 18 - Prob. 5WWTSCh. 18 - Prob. 6WWTSCh. 18 - Prob. 7WWTSCh. 18 - All formed elements of the blood except platelets...Ch. 18 - When RBCs die and break down, the globin moiety of...Ch. 18 - Prob. 10WWTSCh. 18 - Prob. 1TYCCh. 18 - Prob. 2TYCCh. 18 - Prob. 3TYCCh. 18 - Prob. 4TYCCh. 18 - Prob. 5TYC
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