MOD MAST A&P W/PEAR ETEXT INST VIS ANA
3rd Edition
ISBN: 9780136782339
Author: Martini
Publisher: PEARSON
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Chapter 18.1, Problem 20SR
Summary Introduction
To label: The structure that is numbered 20 in the given figure of a heart.
Introduction: The heart is a muscular organ. It pumps the blood all over the body through the circulatory system. It pumps deoxygenated blood to the lungs and oxygenated blood to the rest of the body. Thus, the human heart is called a dual pump. The blood vessels and the heart together constitute the cardiovascular system. The study of the heart is called cardiology.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 18 Solutions
MOD MAST A&P W/PEAR ETEXT INST VIS ANA
Ch. 18.1 - Prob. 1RCh. 18.1 - Prob. 2RCh. 18.1 - Prob. 3RCh. 18.1 - Prob. 4RCh. 18.1 - Prob. 5RCh. 18.1 - Prob. 6RCh. 18.1 - The anterior view of the heart is dominated by...Ch. 18.1 - Prob. 8RCh. 18.1 - Name and describe the shallow depressions and...Ch. 18.1 - Prob. 10R
Ch. 18.1 - Prob. 11RCh. 18.1 - Prob. 12RCh. 18.1 - Prob. 13RCh. 18.1 - Prob. 14RCh. 18.1 - Prob. 15RCh. 18.1 - Prob. 16RCh. 18.1 - Prob. 17RCh. 18.1 - Prob. 18RCh. 18.1 - Prob. 19RCh. 18.1 - Prob. 20RCh. 18.1 - Prob. 1LOCh. 18.1 - Prob. 2LOCh. 18.1 - Describe the structure of the pericardium and...Ch. 18.1 - Prob. 4LOCh. 18.1 - Describe the major vessels supplying the heart,...Ch. 18.1 - Prob. 6LOCh. 18.1 - Prob. 7LOCh. 18.1 - Prob. 8LOCh. 18.1 - Prob. 1ICh. 18.1 - Prob. 2ICh. 18.1 - C. Why is it important that cardiac tissue contain...Ch. 18.1 - Prob. 4ICh. 18.1 - Labeing: Label each of the structures in this...Ch. 18.1 - Prob. 2SRCh. 18.1 - Prob. 3SRCh. 18.1 - Prob. 4SRCh. 18.1 - Prob. 5SRCh. 18.1 - Prob. 6SRCh. 18.1 - Prob. 7SRCh. 18.1 - Prob. 8SRCh. 18.1 - Prob. 9SRCh. 18.1 - Prob. 10SRCh. 18.1 - Prob. 11SRCh. 18.1 - Prob. 12SRCh. 18.1 - Prob. 13SRCh. 18.1 - Prob. 14SRCh. 18.1 - Prob. 15SRCh. 18.1 - Prob. 16SRCh. 18.1 - Prob. 17SRCh. 18.1 - Prob. 18SRCh. 18.1 - Prob. 19SRCh. 18.1 - Prob. 20SRCh. 18.1 - Prob. 21SRCh. 18.1 - Prob. 22SRCh. 18.1 - Prob. 23SRCh. 18.1 - Prob. 24SRCh. 18.1 - Prob. 25SRCh. 18.1 - Prob. 26SRCh. 18.1 - Prob. 27SRCh. 18.1 - Prob. 28SRCh. 18.1 - Prob. 29SRCh. 18.1 - Prob. 30SRCh. 18.1 - Prob. 31SRCh. 18.1 - Prob. 32SRCh. 18.1 - Matching: Match each lettered term with the most...Ch. 18.1 - Prob. 34SRCh. 18.1 - Prob. 35SRCh. 18.2 - Prob. 1RCh. 18.2 - Prob. 2RCh. 18.2 - Prob. 3RCh. 18.2 - Prob. 4RCh. 18.2 - Why does tetany not occur in cardiac muscle?
Ch. 18.2 - Prob. 6RCh. 18.2 - Prob. 7RCh. 18.2 - Prob. 8RCh. 18.2 - Prob. 9RCh. 18.2 - Prob. 10RCh. 18.2 - Prob. 11RCh. 18.2 - Prob. 12RCh. 18.2 - Prob. 13RCh. 18.2 - Prob. 14RCh. 18.2 - Prob. 15RCh. 18.2 - Prob. 16RCh. 18.2 - Prob. 1LOCh. 18.2 - Prob. 2LOCh. 18.2 - Prob. 3LOCh. 18.2 - Prob. 4LOCh. 18.2 - Prob. 5LOCh. 18.2 - Describe the factors affecting the heart rate.
Ch. 18.2 - Prob. 7LOCh. 18.2 - Prob. 8LOCh. 18.2 - Prob. 1ICh. 18.2 - Prob. 2ICh. 18.2 - Prob. 3ICh. 18.2 - Prob. 4ICh. 18.2 - Prob. 5ICh. 18.2 - Prob. 1SRCh. 18.2 - Prob. 2SRCh. 18.2 - Prob. 3SRCh. 18.2 - Prob. 4SRCh. 18.2 - P wave
cardiac output
autorhythmicity
“lubb”...Ch. 18.2 - Prob. 6SRCh. 18.2 - Prob. 7SRCh. 18.2 - Prob. 8SRCh. 18.2 - Prob. 9SRCh. 18.2 - Prob. 10SRCh. 18.2 - Prob. 11SRCh. 18.2 - Prob. 12SRCh. 18.2 - Prob. 13SRCh. 18.2 - Prob. 14SRCh. 18.2 - Prob. 15SRCh. 18.2 - Prob. 16SRCh. 18.2 - Prob. 17SRCh. 18 - Prob. 1CRQCh. 18 - Prob. 2CRQCh. 18 - Prob. 3CRQCh. 18 - Prob. 4CRQCh. 18 - Prob. 5CRQCh. 18 - Prob. 6CRQCh. 18 - Prob. 7CRQCh. 18 - Prob. 8CRQCh. 18 - Prob. 9CRQCh. 18 - Prob. 10CRQCh. 18 - Prob. 11CRQCh. 18 - Prob. 12CRQCh. 18 - Prob. 13CRQCh. 18 - Prob. 14CRQCh. 18 - Prob. 15CRQCh. 18 - Prob. 16CRQCh. 18 - Prob. 17CRQCh. 18 - Prob. 18CRQCh. 18 - Prob. 19CRQCh. 18 - Prob. 20CRQCh. 18 - Prob. 1CICh. 18 - Prob. 2CICh. 18 - Prob. 3CI
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