The reason why the central effector molecule cytochrome c in apoptosis was not found in the many genetic screens for “death” genes that have been carried out in C. elegans Concept introduction: Regulated cell death is a counterintuitive yet crucial process in eukaryotic metazoan organisms. Apoptosis is defined as programmed cell death. Cytochrome c is an electron carrier which is normally present inside the mitochondria. When apoptosis is initiated, the cytochrome c is exported to the cytosol from the mitochondria. Cytochrome c then activates the apoptotic proteins (caspases) through a series of mechanisms. Caspases are proteases which cause cell death.

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Chapter 18, Problem 4P

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To explain: The reason why the central effector molecule cytochrome c in apoptosis was not found in the many genetic screens for “death” genes that have been carried out in C. elegans

Concept introduction: Regulated cell death is a counterintuitive yet crucial process in eukaryotic metazoan organisms. Apoptosis is defined as programmed cell death. Cytochrome c is an electron carrier which is normally present inside the mitochondria. When apoptosis is initiated, the cytochrome c is exported to the cytosol from the mitochondria. Cytochrome c then activates the apoptotic proteins (caspases) through a series of mechanisms. Caspases are proteases which cause cell death.

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