Chapter 18, Problem 36P

Interpretation Introduction

Interpretation:

The products A, B, C, and D formed from the sequence of steps from the given starting material, are to be determined.

Concept Introduction:

▸ LDA is the lithium disopyramide. It is a strong base.

▸ In ${\text{S}}_{\text{N}}\text{2}$ reaction, one bond is broken and one bond is formed. In ${\text{S}}_{\text{N}}\text{2}$ reaction, the nucleophile attacks the carbon with less steric hindrance. The ${\text{S}}_{\text{N}}\text{2}$ reaction gives inversion. The reaction takes place in the polar aprotic solvent.

▸ Alkylation of the ketone takes place with the help of lithium enolates.

▸ Sodium hydride is used to generate the enolate ions.

▸ In the diels-alder reaction, two sigma bonds are formed from an expansion of the pi bond of the diene and dienophile.

▸ Ketones react with secondary amines in order to form compounds called enamines.