Human Anatomy (9th Edition)
9th Edition
ISBN: 9780134320762
Author: Frederic H. Martini, Robert B. Tallitsch, Judi L. Nath
Publisher: PEARSON
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Chapter 18, Problem 2CT
Jared is 10 months old, and his pediatrician diagnoses him with otitis media. What does the physician tell Jared's mother?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 18 Solutions
Human Anatomy (9th Edition)
Ch. 18 - Using the diagram, fill in the blanks below with...Ch. 18 - 2. A receptor that is especially common in the...Ch. 18 - Fine touch and pressure receptors provide detailed...Ch. 18 - Receptors in the saccule and utricle provide...Ch. 18 - 5. Deep to the subcutaneous layer, the eyelids are...Ch. 18 - Prob. 6RFTCh. 18 - Prob. 7RFTCh. 18 - Mechanoreceptors that detect pressure changes in...Ch. 18 - Prob. 9RFTCh. 18 - Auditory information about the frequency and...
Ch. 18 - Fill in the blanks below with the proper...Ch. 18 - Prob. 1RCCh. 18 - Prob. 2RCCh. 18 - 3. A person salivates when anticipating eating a...Ch. 18 - Prob. 4RCCh. 18 - 5. What could stimulate the release of an...Ch. 18 - Prob. 6RCCh. 18 - Prob. 7RCCh. 18 - Prob. 8RCCh. 18 - Prob. 9RCCh. 18 - Prob. 10RCCh. 18 - 1. Beth has surgery to remove some polyps...Ch. 18 - 2. Jared is 10 months old, and his pediatrician...Ch. 18 - Prob. 3CT
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