Chapter 18, Problem 2A

Summary Introduction

To write:

Many serological tests use the antibodies against the particular pathogen but the Salmonella typhi has three antigens, such as the IgM antibodies production is deficient  in nature, and production is made by hybridoma technology.

Given:

Production of antibodies by the Salmonella typhi for the serological test to confirm the presence of antigen in humans.

Introduction:

Salmonella typhi is a gram negative bacteria which is the causative agent for typhoid fever. When it is infected to a person, his immune system produces IgG, IgM and IgA antibodies, since it has three antigens but there is a high specificity in IgM antibody compared to IgG antibody. Widal test often gives false-positive results with other gram negative bacteria.