What is Life? A Guide to Biology
3rd Edition
ISBN: 9781464135958
Author: Jay Phelan
Publisher: W.H. Freeman & Co
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Chapter 18, Problem 12MC
Summary Introduction
Introduction:
When suitable conditions for germination prevail, seed starts to germinate. Initially water is absorbed, causing the embryo to enlarge and the seed coat to burst. Utilizing the fat and starch reserves of the endosperm and embryo,
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Chapter 18 Solutions
What is Life? A Guide to Biology
Ch. 18 - Prob. 1SACh. 18 - Prob. 2SACh. 18 - Prob. 3SACh. 18 - Prob. 4SACh. 18 - Prob. 5SACh. 18 - Prob. 6SACh. 18 - Prob. 7SACh. 18 - Prob. 8SACh. 18 - Prob. 9SACh. 18 - Prob. 10SA
Ch. 18 - Prob. 11SACh. 18 - Prob. 12SACh. 18 - Prob. 13SACh. 18 - Prob. 14SACh. 18 - Prob. 15SACh. 18 - Prob. 16SACh. 18 - Prob. 1MCCh. 18 - Prob. 2MCCh. 18 - Prob. 3MCCh. 18 - Prob. 4MCCh. 18 - Prob. 5MCCh. 18 - Prob. 6MCCh. 18 - Prob. 7MCCh. 18 - Prob. 8MCCh. 18 - Prob. 9MCCh. 18 - Prob. 10MCCh. 18 - Prob. 11MCCh. 18 - Prob. 12MCCh. 18 - Prob. 13MCCh. 18 - Prob. 14MCCh. 18 - Prob. 15MC
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