To suggest: The enzyme that might be deficient in the child and to propose a treatment. Introduction: The vomiting after the child is fed is related to the symptoms of disease called as phenylketonuria. The physical development and weight of the child are below normal. White patches present in the hair of child are also included in the symptoms of phenylketonuria disease.

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Answer 1

Question

Chapter 18, Problem 11P

(a)

Summary Introduction

To suggest: The enzyme that might be deficient in the child and to propose a treatment.

Introduction:

The vomiting after the child is fed is related to the symptoms of disease called as phenylketonuria. The physical development and weight of the child are below normal. White patches present in the hair of child are also included in the symptoms of phenylketonuria disease.

(b)

Summary Introduction

To determine: The reason for the presence of phenylalanine in urine in larger amounts.

Introduction:

The enzyme phenylalanine hydroxylase is necessary for the catabolism of amino acid phenylalanine. This amino acid is present in the tissues and blood in body. It is excreted through the urinary passage.

(c)

Summary Introduction

To determine: The source of phenylpyruvate and phenyllactate. Also determine the reason that this pathway comes into play when the concentration of phenylalanine rises.

Introduction:

The metabolism of phenylalanine in the human body does not require the enzyme phenylalanine hydroxylase. The metabolism process takes place in the absence of phenylalanine hydroxylase enzyme.

(d)

Summary Introduction

To determine: The reason that boy’s hair contains patches of white color.

Introduction:

The white patches in the hair of boy are observed due to the absence of melanin pigment in that area. The melanin is the pigment which decides the color of the skin. It appears during phenylketonuria diseases.

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

Question

Chapter 18, Problem 11P

(a)

Summary Introduction

To suggest: The enzyme that might be deficient in the child and to propose a treatment.

Introduction:

The vomiting after the child is fed is related to the symptoms of disease called as phenylketonuria. The physical development and weight of the child are below normal. White patches present in the hair of child are also included in the symptoms of phenylketonuria disease.

(b)

Summary Introduction

To determine: The reason for the presence of phenylalanine in urine in larger amounts.

Introduction:

The enzyme phenylalanine hydroxylase is necessary for the catabolism of amino acid phenylalanine. This amino acid is present in the tissues and blood in body. It is excreted through the urinary passage.

(c)

Summary Introduction

To determine: The source of phenylpyruvate and phenyllactate. Also determine the reason that this pathway comes into play when the concentration of phenylalanine rises.

Introduction:

The metabolism of phenylalanine in the human body does not require the enzyme phenylalanine hydroxylase. The metabolism process takes place in the absence of phenylalanine hydroxylase enzyme.

(d)

Summary Introduction

To determine: The reason that boy’s hair contains patches of white color.

Introduction:

The white patches in the hair of boy are observed due to the absence of melanin pigment in that area. The melanin is the pigment which decides the color of the skin. It appears during phenylketonuria diseases.

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Answer 3

Question

Chapter 18, Problem 11P

(a)

Summary Introduction

To suggest: The enzyme that might be deficient in the child and to propose a treatment.

Introduction:

The vomiting after the child is fed is related to the symptoms of disease called as phenylketonuria. The physical development and weight of the child are below normal. White patches present in the hair of child are also included in the symptoms of phenylketonuria disease.

(b)

Summary Introduction

To determine: The reason for the presence of phenylalanine in urine in larger amounts.

Introduction:

The enzyme phenylalanine hydroxylase is necessary for the catabolism of amino acid phenylalanine. This amino acid is present in the tissues and blood in body. It is excreted through the urinary passage.

(c)

Summary Introduction

To determine: The source of phenylpyruvate and phenyllactate. Also determine the reason that this pathway comes into play when the concentration of phenylalanine rises.

Introduction:

The metabolism of phenylalanine in the human body does not require the enzyme phenylalanine hydroxylase. The metabolism process takes place in the absence of phenylalanine hydroxylase enzyme.

(d)

Summary Introduction

To determine: The reason that boy’s hair contains patches of white color.

Introduction:

The white patches in the hair of boy are observed due to the absence of melanin pigment in that area. The melanin is the pigment which decides the color of the skin. It appears during phenylketonuria diseases.

Expert Solution & Answer

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Answer 4

Question

Chapter 18, Problem 11P

(a)

Summary Introduction

To suggest: The enzyme that might be deficient in the child and to propose a treatment.

Introduction:

The vomiting after the child is fed is related to the symptoms of disease called as phenylketonuria. The physical development and weight of the child are below normal. White patches present in the hair of child are also included in the symptoms of phenylketonuria disease.

(b)

Summary Introduction

To determine: The reason for the presence of phenylalanine in urine in larger amounts.

Introduction:

The enzyme phenylalanine hydroxylase is necessary for the catabolism of amino acid phenylalanine. This amino acid is present in the tissues and blood in body. It is excreted through the urinary passage.

(c)

Summary Introduction

To determine: The source of phenylpyruvate and phenyllactate. Also determine the reason that this pathway comes into play when the concentration of phenylalanine rises.

Introduction:

The metabolism of phenylalanine in the human body does not require the enzyme phenylalanine hydroxylase. The metabolism process takes place in the absence of phenylalanine hydroxylase enzyme.

(d)

Summary Introduction

To determine: The reason that boy’s hair contains patches of white color.

Introduction:

The white patches in the hair of boy are observed due to the absence of melanin pigment in that area. The melanin is the pigment which decides the color of the skin. It appears during phenylketonuria diseases.

Expert Solution & Answer

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Answer 5

Chapter 18, Problem 11P

(a)

Summary Introduction

To suggest: The enzyme that might be deficient in the child and to propose a treatment.

Introduction:

The vomiting after the child is fed is related to the symptoms of disease called as phenylketonuria. The physical development and weight of the child are below normal. White patches present in the hair of child are also included in the symptoms of phenylketonuria disease.

(b)

Summary Introduction

To determine: The reason for the presence of phenylalanine in urine in larger amounts.

Introduction:

The enzyme phenylalanine hydroxylase is necessary for the catabolism of amino acid phenylalanine. This amino acid is present in the tissues and blood in body. It is excreted through the urinary passage.

(c)

Summary Introduction

To determine: The source of phenylpyruvate and phenyllactate. Also determine the reason that this pathway comes into play when the concentration of phenylalanine rises.

Introduction:

The metabolism of phenylalanine in the human body does not require the enzyme phenylalanine hydroxylase. The metabolism process takes place in the absence of phenylalanine hydroxylase enzyme.

(d)

Summary Introduction

To determine: The reason that boy’s hair contains patches of white color.

Introduction:

The white patches in the hair of boy are observed due to the absence of melanin pigment in that area. The melanin is the pigment which decides the color of the skin. It appears during phenylketonuria diseases.

Answer 6

Chapter 18, Problem 11P

(a)

Summary Introduction

To suggest: The enzyme that might be deficient in the child and to propose a treatment.

Introduction:

The vomiting after the child is fed is related to the symptoms of disease called as phenylketonuria. The physical development and weight of the child are below normal. White patches present in the hair of child are also included in the symptoms of phenylketonuria disease.

Answer 7

Chapter 18, Problem 11P

(a)

Summary Introduction

To suggest: The enzyme that might be deficient in the child and to propose a treatment.

Introduction:

The vomiting after the child is fed is related to the symptoms of disease called as phenylketonuria. The physical development and weight of the child are below normal. White patches present in the hair of child are also included in the symptoms of phenylketonuria disease.

Answer 8

(b)

Summary Introduction

To determine: The reason for the presence of phenylalanine in urine in larger amounts.

Introduction:

The enzyme phenylalanine hydroxylase is necessary for the catabolism of amino acid phenylalanine. This amino acid is present in the tissues and blood in body. It is excreted through the urinary passage.

Answer 9

(b)

Summary Introduction

To determine: The reason for the presence of phenylalanine in urine in larger amounts.

Introduction:

The enzyme phenylalanine hydroxylase is necessary for the catabolism of amino acid phenylalanine. This amino acid is present in the tissues and blood in body. It is excreted through the urinary passage.

Answer 10

(c)

Summary Introduction

To determine: The source of phenylpyruvate and phenyllactate. Also determine the reason that this pathway comes into play when the concentration of phenylalanine rises.

Introduction:

The metabolism of phenylalanine in the human body does not require the enzyme phenylalanine hydroxylase. The metabolism process takes place in the absence of phenylalanine hydroxylase enzyme.

Answer 11

(c)

Summary Introduction

To determine: The source of phenylpyruvate and phenyllactate. Also determine the reason that this pathway comes into play when the concentration of phenylalanine rises.

Introduction:

The metabolism of phenylalanine in the human body does not require the enzyme phenylalanine hydroxylase. The metabolism process takes place in the absence of phenylalanine hydroxylase enzyme.

Answer 12

(d)

Summary Introduction

To determine: The reason that boy’s hair contains patches of white color.

Introduction:

The white patches in the hair of boy are observed due to the absence of melanin pigment in that area. The melanin is the pigment which decides the color of the skin. It appears during phenylketonuria diseases.

Answer 13

(d)

Summary Introduction

To determine: The reason that boy’s hair contains patches of white color.

Introduction:

The white patches in the hair of boy are observed due to the absence of melanin pigment in that area. The melanin is the pigment which decides the color of the skin. It appears during phenylketonuria diseases.

Answer 14

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Answer 15

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Answer 16

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Answer 17

Ch. 18 - Prob. 1P Ch. 18 - Prob. 2P Ch. 18 - Prob. 3P Ch. 18 - Prob. 4P Ch. 18 - Prob. 5P Ch. 18 - Prob. 6P Ch. 18 - Prob. 7P Ch. 18 - Prob. 8P Ch. 18 - Prob. 9P Ch. 18 - Prob. 10P

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To determine: The reason that boy’s hair contains patches of white color. Introduction: The white patches in the hair of boy are observed due to the absence of melanin pigment in that area. The melanin is the pigment which decides the color of the skin. It appears during phenylketonuria diseases.

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