To name: The three structural categories of circulating hormones and give examples within each category. Concept introduction: The endocrine system is the chemical signaling system that uses blood vessels as information channels. This system interacts with other body cells through hormone production. There are three general categories of circulating hormones, namely steroid, biogenic amines , and proteins. All of them differ in their solubility influences which can influence the transport of hormones in the blood and their interactions with their target cells.

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The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions. 1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction? 2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe: a) What molecule do you recommend for the trial. Why? b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for? 3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale. 4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale. Mutation 1 Mutation 2

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Chapter 17.3, Problem 6LO

Summary Introduction

To name: The three structural categories of circulating hormones and give examples within each category.

Concept introduction: The endocrine system is the chemical signaling system that uses blood vessels as information channels. This system interacts with other body cells through hormone production. There are three general categories of circulating hormones, namely steroid, biogenic amines, and proteins. All of them differ in their solubility influences which can influence the transport of hormones in the blood and their interactions with their target cells.

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The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions. 1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction? 2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe: a) What molecule do you recommend for the trial. Why? b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for? 3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale. 4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale. Mutation 1 Mutation 2

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