CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
8th Edition
ISBN: 9781259880193
Author: SALADIN
Publisher: MCGRAW-HILL HIGHER EDUCATION
expand_more
expand_more
format_list_bulleted
Videos
Question
Chapter 17, Problem 5TYR
Summary Introduction
Introduction:
Peptide hormones are synthesized like other protein molecules. They are 3 to ≥ 200 amino acid long chains. Insulin is the large peptide hormone (protein) secreted by the pancreatic islets. The insulin gene is transcribed into the mRNA molecule that codes for insulin protein. Ribosomes bind and read the mRNA molecule and synthesize peptide with the help of tRNA. The rough endoplasmic reticulum and Golgi complex modify the amino acid peptide to mature hormone (protein). The middle portion of the proinsulin (single amino acid chain) is known as the connecting peptide. The connecting peptide (31 amino acids long) is removed from the proinsulin, and the two polypeptide (30 and 21 amino acids long) chains are linked by disulfide bridges to produce the mature insulin molecule.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
What is Prader–Willi syndrome?
a.
A genetic disorder characterized by loss of appetite
b.
Fat accumulation in the liver of leptin-resistant patients
c.
A failure to adapt to alternating periods of excess and inadequate energy intake
d.
A genetic disorder resulting in obesity
e.
Altered receptor activity for ghrelin
What do glucocorticoids and glucagon hav in common? They signal for?
a. glycogen synthesis
b. catabolism of expendable proteins
c. production of cholesterol and steriods
A. What is the difference between preproinsulin and proinsulin?
B. What is cleaved out of proinsulin to allow the mature insulin molecule to be formed?
C. What is the C peptide and why is it medically significant?
D. What is the purpose of the signal sequence and why isn’t it present in the mature insulin molecule?
Chapter 17 Solutions
CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
Ch. 17.1 - Define the word hormone and distinguish a hormone...Ch. 17.1 - Prob. 2BYGOCh. 17.1 - Prob. 3BYGOCh. 17.1 - Prob. 4BYGOCh. 17.1 - Discuss why the target-cell concept is essential...Ch. 17.1 - The importance of intercellular communication for...Ch. 17.1 - The general term for the cells and glands that...Ch. 17.1 - Prob. 3AYLOCh. 17.1 - Prob. 4AYLOCh. 17.1 - Prob. 5AYLO
Ch. 17.2 - Prob. 6BYGOCh. 17.2 - Prob. 7BYGOCh. 17.2 - Prob. 8BYGOCh. 17.2 - In what sense does the pituitary take orders from...Ch. 17.2 - Prob. 10BYGOCh. 17.2 - Prob. 1AYLOCh. 17.2 - Prob. 2AYLOCh. 17.2 - Prob. 3AYLOCh. 17.2 - Two hormones synthesized in the hypothalamus and...Ch. 17.2 - Prob. 5AYLOCh. 17.2 - Two hormones secreted by the posterior pituitary,...Ch. 17.2 - Prob. 7AYLOCh. 17.2 - Prob. 8AYLOCh. 17.3 - Prob. 11BYGOCh. 17.3 - Prob. 12BYGOCh. 17.3 - Prob. 13BYGOCh. 17.3 - Prob. 14BYGOCh. 17.3 - Prob. 15BYGOCh. 17.3 - Prob. 16BYGOCh. 17.3 - Prob. 1AYLOCh. 17.3 - Prob. 2AYLOCh. 17.3 - Prob. 3AYLOCh. 17.3 - Anatomy of the parathyroid glands; their hormone...Ch. 17.3 - Prob. 5AYLOCh. 17.3 - Prob. 6AYLOCh. 17.3 - Three tissue zones of the adrenal cortex, the...Ch. 17.3 - Prob. 8AYLOCh. 17.3 - Prob. 9AYLOCh. 17.3 - Hormones produced by the following tissues and...Ch. 17.4 - What are the three chemical classes of hormones?...Ch. 17.4 - Prob. 18BYGOCh. 17.4 - Prob. 19BYGOCh. 17.4 - Prob. 20BYGOCh. 17.4 - Prob. 21BYGOCh. 17.4 - Prob. 1AYLOCh. 17.4 - Prob. 2AYLOCh. 17.4 - Prob. 3AYLOCh. 17.4 - Prob. 4AYLOCh. 17.4 - The Types of stimuli that elicit hormone...Ch. 17.4 - Thyroid hormone synthesis and secretionCh. 17.4 - Prob. 7AYLOCh. 17.4 - Prob. 8AYLOCh. 17.4 - Which hormones require second messengers to...Ch. 17.4 - How signal amplification enables small amounts of...Ch. 17.4 - How target cells modulate their hormone...Ch. 17.4 - Three kinds of interactions that can occur when...Ch. 17.4 - Prob. 13AYLOCh. 17.5 - Define stress from the standpoint of...Ch. 17.5 - Describe the stages of the general adaptation...Ch. 17.5 - Prob. 24BYGOCh. 17.5 - Prob. 1AYLOCh. 17.5 - Prob. 2AYLOCh. 17.5 - The three stages of the stress response; the...Ch. 17.6 - Prob. 25BYGOCh. 17.6 - Prob. 26BYGOCh. 17.6 - Prob. 27BYGOCh. 17.6 - Paracrine and autocrine secretions, examples, and...Ch. 17.6 - The general structure and metabolic precursor of...Ch. 17.6 - Prob. 3AYLOCh. 17.6 - Prob. 4AYLOCh. 17.6 - Prob. 5AYLOCh. 17.7 - Prob. 28BYGOCh. 17.7 - Prob. 29BYGOCh. 17.7 - Prob. 30BYGOCh. 17.7 - Prob. 1AYLOCh. 17.7 - Myxedema, endemic goiter, and toxic goiterCh. 17.7 - Effects of hypo- and hyperparathyroidismCh. 17.7 - Cushing syndrome and adrenogenital syndromeCh. 17.7 - Prob. 5AYLOCh. 17.7 - Prob. 6AYLOCh. 17.7 - Prob. 7AYLOCh. 17.7 - Consequences of inadequately treated DM and why...Ch. 17 - CRH secretion would not raise the blood...Ch. 17 - Prob. 2TYRCh. 17 - Prob. 3TYRCh. 17 - Prob. 4TYRCh. 17 - Prob. 5TYRCh. 17 - Prob. 6TYRCh. 17 - Prob. 7TYRCh. 17 - Prob. 8TYRCh. 17 - Prob. 9TYRCh. 17 - Prostaglandins are derived from a. phospholipase....Ch. 17 - Prob. 11TYRCh. 17 - Prob. 12TYRCh. 17 - Growth hormone hypersecretion in adulthood causes...Ch. 17 - Prob. 14TYRCh. 17 - Prob. 15TYRCh. 17 - Prob. 16TYRCh. 17 - Target cells can reduce pituitary secretion by a...Ch. 17 - Prob. 18TYRCh. 17 - Prob. 19TYRCh. 17 - ______ is a process in which a cell increases its...Ch. 17 - adeno-Ch. 17 - Prob. 2BYMVCh. 17 - Prob. 3BYMVCh. 17 - Prob. 4BYMVCh. 17 - Prob. 5BYMVCh. 17 - Prob. 6BYMVCh. 17 - Prob. 7BYMVCh. 17 - Prob. 8BYMVCh. 17 - Prob. 9BYMVCh. 17 - Prob. 10BYMVCh. 17 - Castration would lower a mans blood gonadotropin...Ch. 17 - Prob. 2WWTSCh. 17 - Prob. 3WWTSCh. 17 - Prob. 4WWTSCh. 17 - Prob. 5WWTSCh. 17 - The great majority of cases of diabetes mellitus...Ch. 17 - Prob. 7WWTSCh. 17 - A deficiency of dietary iodine would lead to...Ch. 17 - Prob. 9WWTSCh. 17 - Prob. 10WWTSCh. 17 - Prob. 1TYCCh. 17 - Suppose you were browsing in a health-food store...Ch. 17 - Prob. 3TYCCh. 17 - Prob. 4TYCCh. 17 - A young man is involved in a motorcycle accident...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- As glucagon binding to liver and adipocytes increases, numerous responses occur except which of the following? a. Lipid synthesis is inhibited b. Hormone sensitive lipase is inhibited c. cAMP levels increase d. Protein kinase A is activatedarrow_forwardBased on your understanding of the binding of insulin, select all of the following events that you would expect to occur in muscle cells due to insulin binding to receptors.Group of answer choices a. Glycogen synthesis is activated b. PFK is stabilized in the R-state and glycolysis is activated c. GLUT4 (transporters) are increased in concentration at the plasma membrane d. Fructose 2,6-bisphosphate increased levels aid in stabilization of the T-state fructose 1,6-bisphosphatase e. Gluconeogenesis is activated in response to elevated fructose 2,6-bisphosphate levels f. Phosphorylation cascades allow for covalent modifications that would aid in the breakdown of glycogen to allow for increased levels of glucose 6-phosphate in the cell g. Hexokinase is inhibited so glucose will not be brought into the cell in high amounts h. Glycogen breakdown pathway is inactivatedarrow_forwardNovolog differs from "normal" insulin in that: Select one: a. An aspartic acid has been substituted for proline at B28 b. The proline at B28 and the lysine at B29 have been reversed c. A glycine has been substituten in at A21, and two new arginines have been added as B31 and B32 d. A "C-peptide" chain has been added e. The usual insulin molecule has been combined with zinc isophanearrow_forward
- Which of the following classes of compounds stimulates the release of insulin from pancreatic β-cells? a. Thiourylenes b. Biguanides c. Progestins d. Sulfonylureas e. α-Glucosides inhibitorsarrow_forwarda. What hormone is released in response to increased blood glucose? 2. b. The binding of this hormone to its receptor increases the rate of action of a particular transporter. What transporter is this? c. How is the rate increased? d. What enzyme directly involved in glycogen metabolism is activated by this hormone?arrow_forwardDefine the following terms: a. hyperosmolar hyperglycemic nonketosis b. insulin resistance c. JNK d. PKCθ e. PKCεarrow_forward
- How are peptide hormones transported in the bloodstream? A. Peptide hormones are hydrophobic and need a hydrophilic transport protein to help them be transported in the blood B. Peptide are are soluble in , and can be transported without modification C. Peptide hormones are hydrophobic are soluble in plasma, and can be transported with modification D. Peptide hormones are hydrophilic and need a hydrophilic transport protein to help them transported in the blood.arrow_forwardHormone X appears to regulate the blood concentration of chemical Y via a negative feedback loop. a. Predict what happens to the secretion of hormone X when the blood concentration of chemical Y decreases. b. What effect will this likely have on the blood concentration of chemical Y?c. Predict what happens to the secretion of hormone X when the blood concentration of chemical Y increases.arrow_forwardWhich of the following statements about Pyruvate Kinase is true? a. Pyruvate kinase is activated by Fructose 1,6-bisphosphate b. Pyruvate kinase is inactivated by the Hormone Insulin c. Pyruvate kinase is activated by the hormone Glucagon d. Pyruvate Kinase is activated by Fructose 1,6-bisphosphatearrow_forward
- Stretch of the stomach is an important cue for the regulation of food intake. The brain receives information about stomach stretch from: a. sensory receptors on the skin of the abdomen b. the hormone angiotensin c. visual feedback d. the vagus nerve Phenylethanolamine N-methyltransferase (PNMT) is an enzyme that converts norepinephrine into epinephrine. Which of the following would you expect after treatment with an inhibitor of PNMT? a. Cells that normally use dopamine as a neurotransmitter would now release epinephrine b. Cells that normally use epinephrine as a neurotransmitter would now release norepinephrine c. Cells that normally use epinephrine as a neurotransmitter would stop releasing neurotransmitterarrow_forwardHow would the addition of a protein kinase A inhibitor affect the response of an adipocyte to glucagon? A. A protein kinase A inhibitor would block glucagon from binding to its receptor. B. A protein kinase A inhibitor would increase the cell's response to glucagon, enhancing fatty acid mobilization. C. A protein kinase A inhibitor would not affect the cell's response to glucagon. D. A protein kinase A inhibitor would decrease the cell's response to glucagon, weakening the signal for fatty acid mobilization.arrow_forwardIslet cells in the pancreas are actively synthesizing and secreting insulin into the bloodstream. A scientist purifies different membranous fractions of these islet cells. In which fraction would she find insulin or its intermediates?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
What is Metabolism?; Author: Stated Clearly;https://www.youtube.com/watch?v=nRq6N5NGD1U;License: Standard youtube license