Organic Chemistry 3rd.ed. Klein Evaluation/desk Copy
Organic Chemistry 3rd.ed. Klein Evaluation/desk Copy
3rd Edition
ISBN: 9781119320524
Author: Klein
Publisher: WILEY
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Chapter 17, Problem 56IP
Interpretation Introduction

Interpretation: For the given compounds, which hold greater promise as a potential anti histamine should be found and its sedative property should explained

Concept introduction:

  • Anti-histamines are drugs which treat allergic. It gives relief from nausea and vomiting. Which have sedative property
  •  Anti-histamines  required pharmacophore, is a part of molecular structure that has two aromatic rings separated by one carbon atom, and a tertiary amine
  • The requirement of an odd number of electron pair is called Huckel’s rule. A compound can only be aromatic if the number of π electron in the ring is 2, 6,10,14,18 and so on. This series of number can be expressed mathematically as 4n+2 , where n should be an integer and the compound is aromatic.
  • Each π bond count as two π electron and lone pair also count as two π electron

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Chapter 17 Solutions

Organic Chemistry 3rd.ed. Klein Evaluation/desk Copy

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