Pearson eText Bauman Microbiology with Diseases by Body Systems -- Instant Access (Pearson+)
5th Edition
ISBN: 9780135891018
Author: ROBERT BAUMAN
Publisher: PEARSON+
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Textbook Question
Chapter 17, Problem 4MTF
Modified True/False
4. _________________ ELISA is very easily automated.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 17 Solutions
Pearson eText Bauman Microbiology with Diseases by Body Systems -- Instant Access (Pearson+)
Ch. 17 - Prob. 1TMWCh. 17 - A diagnostician used an ELISA to show that a...Ch. 17 - To obtain immediate immunity against tetanus, a...Ch. 17 - Which of the following vaccine types is commonly...Ch. 17 - Prob. 3MCCh. 17 - When antigen and antibodies combine, maximal...Ch. 17 - An anti-antibody is used when _________. a. an...Ch. 17 - Prob. 6MCCh. 17 - Prob. 7MCCh. 17 - Prob. 8MC
Ch. 17 - Prob. 9MCCh. 17 - Prob. 10MCCh. 17 - Prob. 11MCCh. 17 - An antiserum is ________. a. an anti-antibody b....Ch. 17 - Prob. 13MCCh. 17 - Prob. 14MCCh. 17 - Prob. 15MCCh. 17 - Prob. 1MTFCh. 17 - Prob. 2MTFCh. 17 - Prob. 3MTFCh. 17 - Modified True/False 4. _________________ ELISA is...Ch. 17 - Prob. 5MTFCh. 17 - Match the characteristic in the first column with...Ch. 17 - Identify the chemicals represented by this artists...Ch. 17 - Prob. 2VICh. 17 - Compare and contrast the Chinese practice of...Ch. 17 - What are the advantages and disadvantages of...Ch. 17 - Compare the advantages and disadvantages of...Ch. 17 - How does precipitation differ from agglutination?Ch. 17 - Explain how a pregnancy test works at the...Ch. 17 - Compare and contrast herd immunity and contact...Ch. 17 - How does nephelometry differ from turbidimetry?Ch. 17 - Is it ethical to approve the use of a vaccine that...Ch. 17 - Which is worse: to use a diagnostic test for HIV...Ch. 17 - Discuss the importance of costs and technical...Ch. 17 - What bodily fluids, in addition to blood serum,...Ch. 17 - Why might a serological test give a false positive...Ch. 17 - Some researchers want to distinguish B cells from...Ch. 17 - Describe three ways by which genetic recombinant...Ch. 17 - How does a toxoid vaccine differ from an...Ch. 17 - Explain why many health organizations promote...Ch. 17 - Contrast a hemagglutination test with a viral...Ch. 17 - Prob. 11CTCh. 17 - Draw a picture showing, at both the molecular and...Ch. 17 - Using the following terms, fill in the following...
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