Hole's Human Anatomy & Physiology
15th Edition
ISBN: 9781259864568
Author: SHIER, David, Butler, Jackie, Lewis, Ricki
Publisher: Mcgraw-hill Education,
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Chapter 17, Problem 10P
How are types of teeth adapted to provide specialized functions?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 17 Solutions
Hole's Human Anatomy & Physiology
Ch. 17 - Prob. 1PCh. 17 - 2 Which organs constitute the digestive system?
Ch. 17 - 3 Describe the wall of the alimentary canal.
Ch. 17 - Name the types of movements in the alimentary...Ch. 17 - Prob. 5PCh. 17 - Prob. 6PCh. 17 - How does the tongue function as part of the...Ch. 17 - Where are the tonsils located?Ch. 17 - Prob. 9PCh. 17 - How are types of teeth adapted to provide...
Ch. 17 - Prob. 11PCh. 17 - Explain how a tooth is attached to the bone of the...Ch. 17 - Prob. 13PCh. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Prob. 16PCh. 17 - List the major events of swallowing.Ch. 17 - Prob. 18PCh. 17 - Prob. 19PCh. 17 - Prob. 20PCh. 17 - Why doesn’t the stomach digest itself?Ch. 17 - Prob. 22PCh. 17 - Distinguish among the cephalic, gastric, and...Ch. 17 - Prob. 24PCh. 17 - Prob. 25PCh. 17 - Prob. 26PCh. 17 - Prob. 27PCh. 17 - Prob. 28PCh. 17 - Prob. 29PCh. 17 - List the enzymes in pancreatic juice.Ch. 17 - What are the functions of the enzymes in...Ch. 17 - What regulates secretion of pancreatic juice?Ch. 17 - Locate the liver.Ch. 17 - Review liver functions.Ch. 17 - Prob. 35PCh. 17 - Prob. 36PCh. 17 - Describe the function of the gallbladder.Ch. 17 - How is secretion of bile regulated?Ch. 17 - Prob. 39PCh. 17 - Describe the parts of the small intestine.Ch. 17 - What is the function of an intestinal villus?Ch. 17 - Prob. 42PCh. 17 - Prob. 43PCh. 17 - Prob. 44PCh. 17 - Prob. 45PCh. 17 - Prob. 46PCh. 17 - Prob. 47PCh. 17 - Prob. 48PCh. 17 - Prob. 49PCh. 17 - What stimulus relaxes the ileocecal sphincter?Ch. 17 - Prob. 51PCh. 17 - Prob. 52PCh. 17 - Prob. 53PCh. 17 - Prob. 54PCh. 17 - Prob. 55PCh. 17 - Prob. 56PCh. 17 - Prob. 57PCh. 17 - Prob. 58PCh. 17 - Prob. 59PCh. 17 - Prob. 60PCh. 17 - Prob. 61PCh. 17 - Prob. 1CACh. 17 - Prob. 2CACh. 17 - Prob. 3CACh. 17 - Prob. 4CACh. 17 - Prob. 5CACh. 17 - Prob. 6CACh. 17 - Prob. 7CACh. 17 - Prob. 8CACh. 17 - Prob. 9CACh. 17 - Prob. 10CACh. 17 - Prob. 11CACh. 17 - Prob. 12CACh. 17 - Prob. 13CACh. 17 - Prob. 14CACh. 17 - Describe the locations of the major salivary...Ch. 17 - Prob. 16CACh. 17 - Prob. 17CACh. 17 - Prob. 18CACh. 17 - Prob. 19CACh. 17 - Prob. 20CACh. 17 - Prob. 21CACh. 17 - Prob. 22CACh. 17 - Prob. 23CACh. 17 - Prob. 24CACh. 17 - Prob. 25CACh. 17 - Prob. 26CACh. 17 - Prob. 27CACh. 17 - Prob. 28CACh. 17 - Prob. 29CACh. 17 - Prob. 30CACh. 17 - Prob. 31CACh. 17 - Prob. 32CACh. 17 - Prob. 33CACh. 17 - Prob. 34CACh. 17 - Describe the locations of the parts of the small...Ch. 17 - Prob. 36CACh. 17 - Prob. 37CACh. 17 - Prob. 38CACh. 17 - Prob. 39CACh. 17 - Prob. 40CACh. 17 - Prob. 41CACh. 17 - Prob. 42CACh. 17 - Prob. 43CACh. 17 - Prob. 44CACh. 17 - Prob. 45CACh. 17 - Prob. 46CACh. 17 - Prob. 1IACh. 17 - Prob. 2IACh. 17 - What effect is a before-dinner alcoholic cocktail...Ch. 17 - What type of acid-base imbalance is likely to...Ch. 17 - Prob. 5IA
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