Anatomy & Physiology: The Unity of Form and Function
8th Edition
ISBN: 9781259277726
Author: Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Chapter 16.4, Problem 7AYLO
The bony and membranous labyrinths of the inner ear; the names and distribution of the two inner-ear fluids in relation to the labyrinths
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 16 Solutions
Anatomy & Physiology: The Unity of Form and Function
Ch. 16.1 - Not every sensory receptor is a sense organ....Ch. 16.1 - What does it mean to say sense organs are...Ch. 16.1 - Prob. 3BYGOCh. 16.1 - What is meant by the modality of a stimulus? Give...Ch. 16.1 - Three schemes of receptor classification were...Ch. 16.1 - Nociceptors are tonic rather than phasic...Ch. 16.1 - The definition of receptor and the range of...Ch. 16.1 - Prob. 2AYLOCh. 16.1 - Prob. 3AYLOCh. 16.1 - Prob. 4AYLO
Ch. 16.1 - Prob. 5AYLOCh. 16.1 - Prob. 6AYLOCh. 16.1 - Prob. 7AYLOCh. 16.2 - What stimulus modalities are detected by free...Ch. 16.2 - Prob. 8BYGOCh. 16.2 - Where do most second-order somatosensory neurons...Ch. 16.2 - Explain the phenomenon of referred pain in terms...Ch. 16.2 - Explain the roles of bradykinin, substance P, and...Ch. 16.2 - Three Types of unencapsulated sensory nerve...Ch. 16.2 - Six types of encapsulated nerve endings and how...Ch. 16.2 - The main routes for somatosensory signals from the...Ch. 16.2 - Definitions of pain and nociceptorCh. 16.2 - Differences between fast pain and slow painCh. 16.2 - Differences between somatic and visceral pain, and...Ch. 16.2 - Several chemicals released by injured tissues that...Ch. 16.2 - The general three-neuron pathway typically taken...Ch. 16.2 - Pain pathways from receptors in the head to the...Ch. 16.2 - Pain pathways from the lower body to the cerebral...Ch. 16.2 - Prob. 11AYLOCh. 16.2 - Referred pain and its anatomical basisCh. 16.2 - Prob. 13AYLOCh. 16.2 - Prob. 14AYLOCh. 16.3 - Prob. 12BYGOCh. 16.3 - Prob. 13BYGOCh. 16.3 - Prob. 14BYGOCh. 16.3 - Prob. 15BYGOCh. 16.3 - Prob. 16BYGOCh. 16.3 - Prob. 1AYLOCh. 16.3 - Types, locations, and functions of lingual...Ch. 16.3 - Five primary taste sensations, and sensations...Ch. 16.3 - Prob. 4AYLOCh. 16.3 - Prob. 5AYLOCh. 16.3 - Prob. 6AYLOCh. 16.3 - How odor molecules excite olfactory cellsCh. 16.3 - Prob. 8AYLOCh. 16.3 - Prob. 9AYLOCh. 16.3 - Prob. 10AYLOCh. 16.4 - Prob. 17BYGOCh. 16.4 - Prob. 18BYGOCh. 16.4 - Prob. 19BYGOCh. 16.4 - Prob. 20BYGOCh. 16.4 - Prob. 21BYGOCh. 16.4 - Prob. 22BYGOCh. 16.4 - Prob. 1AYLOCh. 16.4 - Prob. 2AYLOCh. 16.4 - Prob. 3AYLOCh. 16.4 - Prob. 4AYLOCh. 16.4 - Prob. 5AYLOCh. 16.4 - Prob. 6AYLOCh. 16.4 - The bony and membranous labyrinths of the inner...Ch. 16.4 - Prob. 8AYLOCh. 16.4 - Prob. 9AYLOCh. 16.4 - Prob. 10AYLOCh. 16.4 - Prob. 11AYLOCh. 16.4 - Prob. 12AYLOCh. 16.4 - Prob. 13AYLOCh. 16.4 - Prob. 14AYLOCh. 16.4 - The pathway from cochlear nerve to auditory...Ch. 16.4 - Prob. 16AYLOCh. 16.4 - Prob. 17AYLOCh. 16.4 - Prob. 18AYLOCh. 16.4 - Prob. 19AYLOCh. 16.4 - Prob. 20AYLOCh. 16.4 - Prob. 21AYLOCh. 16.4 - The path taken by signals in the vestibular nerve...Ch. 16.4 - Prob. 23AYLOCh. 16.5 - Why can't we see wavelengths of 350 nm or 750 nm?Ch. 16.5 - Prob. 24BYGOCh. 16.5 - Prob. 25BYGOCh. 16.5 - Prob. 26BYGOCh. 16.5 - Prob. 27BYGOCh. 16.5 - Prob. 1AYLOCh. 16.5 - Six extrinsic eye muscles, their anatomy, the eye...Ch. 16.5 - Prob. 3AYLOCh. 16.5 - Prob. 4AYLOCh. 16.5 - Prob. 5AYLOCh. 16.5 - Prob. 6AYLOCh. 16.5 - Prob. 7AYLOCh. 16.5 - General structure of the retina: its two points of...Ch. 16.5 - Prob. 9AYLOCh. 16.5 - Prob. 10AYLOCh. 16.5 - Principles of refraction; points at which...Ch. 16.5 - The difference between enmetropia and lite near...Ch. 16.5 - Histological layers and cell types of the retina....Ch. 16.5 - The structures of rods and cones; where visual...Ch. 16.5 - Differences in rod and cone functionCh. 16.5 - Prob. 16AYLOCh. 16.5 - Prob. 17AYLOCh. 16.5 - Why a single retinal receptor system cannot...Ch. 16.5 - Difference between S, M, and L cones; how neural...Ch. 16.5 - Prob. 20AYLOCh. 16.5 - Prob. 21AYLOCh. 16.5 - Hemidecussation, where it occurs, and how it...Ch. 16 - Hot and cold stimuli are detected by a. free nerve...Ch. 16 - _____is a neurotransmitter that transmits pain...Ch. 16 - Prob. 3TYRCh. 16 - Prob. 4TYRCh. 16 - Prob. 5TYRCh. 16 - Prob. 6TYRCh. 16 - Prob. 7TYRCh. 16 - Prob. 8TYRCh. 16 - The retina receives its oxygen supply from a. the...Ch. 16 - Prob. 10TYRCh. 16 - The most finely detailed vision occurs when an...Ch. 16 - Prob. 12TYRCh. 16 - Prob. 13TYRCh. 16 - Prob. 14TYRCh. 16 - Three rows of________in the cochlea have V-shaped...Ch. 16 - The ______ is a tiny bone that vibrates in the...Ch. 16 - The _____ of the midbrain receives auditory input...Ch. 16 - Prob. 18TYRCh. 16 - Olfactory neurons synapse with mitral cells and...Ch. 16 - In the phenomenon of ______, pain from the viscera...Ch. 16 - bin-Ch. 16 - decuss-Ch. 16 - hemi-Ch. 16 - lacrimo-Ch. 16 - litho-Ch. 16 - maculo-Ch. 16 - noci-Ch. 16 - scoto-Ch. 16 - -sepsisCh. 16 - Prob. 10BYMVCh. 16 - The sensory (afferent) nerve fibers for touch end...Ch. 16 - Prob. 2WWTSCh. 16 - Things we see with the left eye are perceived only...Ch. 16 - Prob. 4WWTSCh. 16 - The vitreous body occupies the posterior chamber...Ch. 16 - Prob. 6WWTSCh. 16 - Prob. 7WWTSCh. 16 - Prob. 8WWTSCh. 16 - Prob. 9WWTSCh. 16 - Prob. 10WWTSCh. 16 - The principle of neural convergence is explained...Ch. 16 - What type of cutaneous receptor enables you to...Ch. 16 - Prob. 3TYCCh. 16 - Prob. 4TYCCh. 16 - Prob. 5TYC
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