VANDER'S HUMAN PHY W/ CONNECT & PROCT +
15th Edition
ISBN: 9781265160920
Author: WIDMAIER
Publisher: MCG
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Chapter 16, Problem A.16RQ
Summary Introduction
To describe: The permissive effects of cortisol and the effects caused by increase in plasma cortisol concentration.
Introduction: Adrenal glands are endocrine glands that are involved in secretion of three major hormones namely adrenalin, aldosterone, and cortisol. Cortisol is a glucocorticoid hormone secreted by adrenal cortex.
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Chapter 16 Solutions
VANDER'S HUMAN PHY W/ CONNECT & PROCT +
Ch. 16 - Prob. 1PICh. 16 - A general principle of physiology is that...Ch. 16 - Prob. 3PICh. 16 - Prob. 4PICh. 16 - Prob. 5PICh. 16 - Using a diagram, summarize the events of the...Ch. 16 - In what two organs does major glycogen storage...Ch. 16 - How do the liver and adipose tissue metabolize...Ch. 16 - How does adipose tissue metabolize absorbed...Ch. 16 - Using a diagram, describe the sources of...
Ch. 16 - What are the effects of saturated and unsaturated...Ch. 16 - What is the significance of the ratio of LDL...Ch. 16 - What are the fates of most of the absorbed amino...Ch. 16 - Using a diagram, summarize the events of the...Ch. 16 - Distinguish between the roles of glycerol and free...Ch. 16 - Prob. A.11RQCh. 16 - Describe several inputs controlling insulin...Ch. 16 - Prob. A.13RQCh. 16 - Prob. A.14RQCh. 16 - List the metabolic effects of epinephrine and the...Ch. 16 - Prob. A.16RQCh. 16 - Prob. A.17RQCh. 16 - Prob. A.18RQCh. 16 - Describe how plasma glucose, insulin, glucagon,...Ch. 16 - Prob. 6PICh. 16 - Prob. 7PICh. 16 - State the formula relating total energy...Ch. 16 - Prob. B.2RQCh. 16 - Prob. B.3RQCh. 16 - Prob. B.4RQCh. 16 - Prob. B.5RQCh. 16 - Prob. B.6RQCh. 16 - Prob. 8PICh. 16 - Prob. 9PICh. 16 - Prob. C.1RQCh. 16 - Prob. C.2RQCh. 16 - Prob. C.3RQCh. 16 - Prob. C.4RQCh. 16 - Prob. C.5RQCh. 16 - What are the major functions of insulin,...Ch. 16 - Prob. 2RRCh. 16 - Which is incorrect?
Fatty acids can be used to...Ch. 16 - Prob. 2RCCh. 16 - Prob. 3RCCh. 16 - Prob. 4RCCh. 16 - Prob. 5RCCh. 16 - The calorigenic effect of thyroid hormones
refers...Ch. 16 - Prob. 7RCCh. 16 - Prob. 8RCCh. 16 - Prob. 9RCCh. 16 - Prob. 10RCCh. 16 - Prob. 11RCCh. 16 - Prob. 12RCCh. 16 - Prob. 13RCCh. 16 - Prob. 14RCCh. 16 - Prob. 15RCCh. 16 - Prob. 1AAECh. 16 - Prob. 2AAECh. 16 - Prob. 3AAECh. 16 - Prob. 4AAECh. 16 - Prob. 5AAECh. 16 - Prob. 6AAECh. 16 - Prob. 7AAECh. 16 - Prob. 1GPACh. 16 - Prob. 2GPACh. 16 - Prob. 3GPA
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